Serdemetan

Serdemetan

SCHEMBL29375950

c1ccc2c(CCNc3ccc(Nc4ccncc4)cc3)c[nH]c2c1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 4/20 0.58
HTR2A P28223 3/20 0.57
HTR1A P08908 2/20 0.57
DRD2 P14416 2/20 0.57
HTR7 P34969 1/20 0.57
HTR6 P50406 1/20 0.57
KMT2A Q03164 3/20 0.55
POLB P06746 1/20 0.55
SLC2A1 P11166 1/20 0.55
RAD52 P43351 1/20 0.55
MEN1 O00255 2/20 0.55
ALDH1A1 P00352 2/20 0.54
HTT P42858 2/20 0.54
KDM4E B2RXH2 1/20 0.54
MC5R P33032 1/20 0.52
MC3R P41968 1/20 0.52
MC1R Q01726 1/20 0.52
USP2 O75604 1/20 0.52
ALOX15 P16050 1/20 0.52
DRD1 P21728 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Serdemetan SCHEMBL3012498 1.00 HRH3 (0.58) HRH3HTR2AHTR1ADRD2HTR7
SCHEMBL12782483 0.92 HDAC3 (0.56) HRH3HTR2AHTR1ADRD2HTR7
SCHEMBL12845524 0.91 HDAC3 (0.53) HRH3HTR2AHTR1ADRD2HTR7
SCHEMBL12782284 0.89 HRH3 (0.61) HRH3HTR2AHTR1ADRD2HTR7
SCHEMBL12845514 0.88 HRH3 (0.54) HRH3HTR2AHTR1ADRD2HTR7
SCHEMBL12845676 0.88 PTGS2 (0.62) HRH3HTR2AHTR1ADRD2HTR7
SCHEMBL8041023 0.87 KMT2A (0.53) HTR2AHTR1ADRD2HTR7HTR6
SCHEMBL12845346 0.87 HRH3 (0.59) HRH3HTR2AHTR1ADRD2HTR7
SCHEMBL8043532 0.87 KMT2A (0.54) HRH3HTR2AHTR1ADRD2HTR7
SCHEMBL12845369 0.86 HRH3 (0.54) HRH3KMT2AMEN1HTTMC5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 226 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3947736-B1 PROGNOSIS METHOD OF CANCER CENTRE NAT RECH SCIENT (FR) 2026-03-11 EP claimed
US-20250312353-A1 DRUG REPURPOSING FOR TREATMENT OF CONGENITAL VASCULAR MALFORMATIONS UNIVERSITY OF SOUTH CAROLINA (US) 2025-10-09 US claimed
US-20250127777-A1 DUAL INHIBITION OF MDM2 AND EIF2-ALPHA INDUCES CELL DEATH IN MULTIPLE CANCER CELL TYPES UNIV COLORADO REGENTS (US) 2025-04-24 US claimed
US-20250049815-A1 25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR TO AMELIORIATE VASCULAR STIFFNESS BUCK INST RES AGING (US) 2025-02-13 US claimed
WO-2024196963-A2 COMPOSITIONS AND METHODS FOR GENOME EDITING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-09-26 WO claimed
US-20240299558-A1 PROTEOLYSIS TARGETING CHIMERAS AND POLYPHARMACOLOGICAL AGENTS TARGETING BCL-2, AND METHODS OF USE THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-09-12 US claimed
EP-4380574-A2 25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR TO AMELIORIATE VASCULAR STIFFNESS Buck Institute for Research on Aging (US) 2024-06-12 EP claimed
WO-2024006252-A1 DUAL INHIBITION OF MDM2 AND EIF2-ALPHA INDUCES CELL DEATH IN MULTIPLE CANCER CELL TYPES THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2024-01-04 WO claimed
CN-117017987-A Pharmaceutical composition for preventing and treating lung cancer, and preparation method and application thereof 中国人民解放军军事科学院军事医学研究院 2023-11-10 CN claimed
US-20230346879-A1 COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2023-11-02 US claimed
CN-116510024-A Composition, preparation method and application thereof 上海复东生物医药有限责任公司 2023-08-01 CN claimed
EP-4157204-A1 DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC Buck Institute for Research on Aging (US) 2023-04-05 EP claimed
WO-2023014718-A2 25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR TO AMELIORIATE VASCULAR STIFFNESS BUCK INSTITUTE FOR RESEARCH ON AGING (US) 2023-02-09 WO claimed
US-20230027472-A1 TARGETING P73 FOR CANCERS RESISTANT TO BH3 MIMETICS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-01-26 US claimed
WO-2022266491-A1 PROTEOLYSIS TARGETING CHIMERAS AND POLYPHARMACOLOGICAL AGENTS TARGETING BCL-2, AND METHODS OF USE THEREOF UNIVERSITY OF MARYLAND, BALTIMORE (US) 2022-12-22 WO claimed
US-11471462-B2 Compositions and methods for detecting and treating diabetes THE BROAD INSTITUTE, INC. (US) 2022-10-18 US claimed
US-20220186321-A1 PROGNOSIS METHOD OF CANCER CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2022-06-16 US claimed
EP-3947736-A1 PROGNOSIS METHOD OF CANCER Centre national de la recherche scientifique (FR) 2022-02-09 EP claimed
US-20220031694-A1 COMBINATION PRODUCT OF BCL-2 INHIBITOR AND MDM2 INHIBITOR AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) 2022-02-03 US claimed
EP-4739310-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) INHIBITOR COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-05-13 EP disclosed
US-12599592-B2 Therapeutic small molecules for treatment of pulmonary hypertension UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2026-04-14 US disclosed
US-20260097028-A1 Methods of Treating Myeloproliferative Neoplasms KARTOS THERAPEUTICS INC (US) 2026-04-09 US disclosed
EP-4719409-A1 TREATMENT OF ENDOMETRIAL CANCER WITH MDM2 INHIBITORS Kartos Therapeutics, Inc. (US) 2026-04-08 EP disclosed
US-12595515-B2 Prognosis method of cancer CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2026-04-07 US disclosed
EP-3947736-B1 PROGNOSIS METHOD OF CANCER CENTRE NAT RECH SCIENT (FR) 2026-03-11 EP disclosed
CN-121586709-A Checkpoint kinase 1 (CHK 1) inhibitor crystal forms and uses thereof 无界生物公司 2026-02-27 CN disclosed
EP-4688770-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITOR CRYSTALLINE FORM AND USES THEREOF Boundless Bio, Inc. (US) 2026-02-11 EP disclosed
EP-4683635-A1 USES OF A CHECKPOINT KINASE 1 (CHK1) INHIBITOR Boundless Bio, Inc. (US) 2026-01-28 EP disclosed
US-20260024617-A1 METHODS AND SYSTEMS FOR PERSONALIZED THERAPIES SCIPHER MEDICINE CORP (US) 2026-01-22 US disclosed
US-12527790-B2 Checkpoint kinase 1 (CHK1) inhibitors and uses thereof BOUNDLESS BIO, INC. (US) 2026-01-20 US disclosed
EP-4676602-A1 COMPOUNDS TARGETING MUTATIONS IN P53 AND USES THEREOF Merck Sharp & Dohme LLC (US) 2026-01-14 EP disclosed
US-20250388602-A1 Tetrahydropyranopyrazole Derivatives for the Treatment of Cancer and Viral Infections GENASE THERAPEUTICS B V (NL) 2025-12-25 US disclosed
US-20250387383-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS KARTOS THERAPEUTICS, INC. (US) 2025-12-25 US disclosed
EP-4653052-A2 TREATMENT OF CANCER HAVING GNAQ OR GNA11 GENETIC MUTATIONS WITH PROTEIN KINASE C INHIBITORS Ideaya Biosciences, Inc. (US) 2025-11-26 EP disclosed
US-20250354117-A1 METHODS OF GENERATING NATURAL KILLER CELLS FROM PLURIPOTENT STEM CELLS AND COMPOSITIONS THEREOF CHILDRENS MEDICAL CT CORP (US) 2025-11-20 US disclosed
WO-2025227060-A1 HETEROCYCLIC INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) IN COMBINATION WITH ADDITIONAL AGENTS FOR USE IN THE TREATMENT OF CANCER INSILICO MEDICINE IP LIMITED (CN) 2025-10-30 WO disclosed
CN-117017987-B Pharmaceutical composition for preventing and treating lung cancer, and preparation method and application thereof 中国人民解放军军事科学院军事医学研究院 2025-10-21 CN disclosed
EP-4629993-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS Kartos Therapeutics (US) 2025-10-15 EP disclosed
EP-4469461-B1 TETRAHYDROPYRANOPYRAZOLE DERIVATIVES FOR THE TREATMENT OF CANCER AND VIRAL INFECTIONS GENASE THERAPEUTICS B V (NL) 2025-10-15 EP disclosed
US-20250312353-A1 DRUG REPURPOSING FOR TREATMENT OF CONGENITAL VASCULAR MALFORMATIONS UNIVERSITY OF SOUTH CAROLINA (US) 2025-10-09 US disclosed
EP-4626433-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITORS COMBINATIONS AND USES THEREOF Boundless Bio, Inc. (US) 2025-10-08 EP disclosed
US-20250288572-A1 COMPOSITIONS AND METHODS FOR TREATING PULMONARY VASCULAR DISEASE UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2025-09-18 US disclosed
EP-4606433-A2 FORMULATIONS COMPRISING HETEROCYCLIC PROTEIN KINASE INHIBITORS Sumitomo Pharma America, Inc. (US) 2025-08-27 EP disclosed
US-20250236841-A1 METHODS TO ENHANCE TUMOR IMMUNOGENICITY AND COMPOSITIONS FOR AUTOLOGOUS CANCER IMMUNOTHERAPEUTIC PRODUCTS USING MODIFIED TUMOR CELLS AND MODIFIED DENDRITIC CELLS AIVITA BIOMEDICAL INC (US) 2025-07-24 US disclosed
US-12351571-B2 Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases ARRAY BIOPHARMA INC. (US) 2025-07-08 US disclosed
US-12350247-B2 Use of APE1/Ref-1 inhibitors for treatment of retinal diseases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2025-07-08 US disclosed
US-20250213601-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR THE TREATMENT OF VIRAL DISEASES Didenko, Kirill (US) 2025-07-03 US disclosed
EP-3908282-B1 TREATMENT OF CANCER HAVING GNAQ OR GNA11 GENETIC MUTATIONS WITH PROTEIN KINASE C INHIBITORS IDEAYA BIOSCIENCES INC (US) 2025-07-02 EP disclosed
CN-120037232-A Methods of treating cancer 卡托斯医疗公司 2025-05-27 CN disclosed
WO-2025106804-A1 COMPOSITIONS AND METHODS FOR CHARACTERIZING HEPATOCYTE STRESS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2025-05-22 WO disclosed
EP-3474849-B1 COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DIABETES BROAD INST INC (US) 2025-05-21 EP disclosed
EP-3924351-B1 CRYSTALLINE FORM OF THE HYDROCHLORIDE SALT OF 2-((1R,4R)-4-((3-(3-(TRIFLUOROMETHYL)PHENYL) IMIDAZO[1,2-B]PYRIDAZIN-6-YL)AMINO)CYCLOHEXYL)PROPAN-2-OL SUMITOMO PHARMA AMERICA INC (US) 2025-05-21 EP disclosed
US-20250134876-A1 METHODS OF TREATING A CANCER OVEREXPRESSING ONE OR MORE BCL-2 FAMILY PROTEINS KARTOS THERAPEUTICS, INC. 2025-05-01 US disclosed
US-20250134877-A1 METHODS OF TREATING CANCER DEPENDENT ON MYC GENE EXPRESSSION KARTOS THERAPEUTICS, INC. 2025-05-01 US disclosed
US-12285427-B2 Treatment of a senescence-associated ocular disease or disorder using a Bcl-xL selective inhibitor UNITY BIOTECHNOLOGY, INC. (US) 2025-04-29 US disclosed
US-20250127777-A1 DUAL INHIBITION OF MDM2 AND EIF2-ALPHA INDUCES CELL DEATH IN MULTIPLE CANCER CELL TYPES UNIV COLORADO REGENTS (US) 2025-04-24 US disclosed
WO-2025076057-A1 SELECTIVE INHIBITION OF MDM2-AMPLIFIED CANCERS USING TARGETED PROTEIN DEGRADERS DANA-FARBER CANCER INSTITUTE, INC. (US) 2025-04-10 WO disclosed
EP-4532486-A1 PYRIDINE CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF Boundless Bio, Inc. (US) 2025-04-09 EP disclosed
US-12268681-B2 Methods of treating myeloproliferative neoplasms KARTOS THERAPEUTICS, INC. (US) 2025-04-08 US disclosed
US-20250090517-A1 Methods of Treating Cancer KARTOS THERAPEUTICS INC (US) 2025-03-20 US disclosed
US-20250078957-A1 Unsupervised Machine Learning Methods AMPEL BIOSOLUTIONS LLC (US) 2025-03-06 US disclosed
CN-119546588-A Pyridine checkpoint kinase 1 (CHK 1) inhibitors and uses thereof 无界生物公司 2025-02-28 CN disclosed
US-20250049815-A1 25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR TO AMELIORIATE VASCULAR STIFFNESS BUCK INST RES AGING (US) 2025-02-13 US disclosed
US-20250025484-A1 POLYMERSOME NANOPARTICLES EXHAUSTING INTRACELLUAR AMINO ACID FOR CANCER THERAPY AND METHODS THEREOF THE UNIVERSITY OF HONG KONG (CN) 2025-01-23 US disclosed
US-20250022541-A1 Unsupervised Machine Learning Methods AMPEL BIOSOLUTIONS LLC (US) 2025-01-16 US disclosed
US-12194031-B2 Compounds for use in regulating follicle maturation AARHUS UNIVERSITET (DK) 2025-01-14 US disclosed
WO-2025007955-A1 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) INHIBITOR COMBINATIONS AND USES THEREOF INSILICO MEDICINE IP LIMITED (CN) 2025-01-09 WO disclosed
US-20240428948-A1 Unsupervised Machine Learning Methods AMPEL BIOSOLUTIONS LLC (US) 2024-12-26 US disclosed
EP-4479973-A1 UNSUPERVISED MACHINE LEARNING METHODS Ampel Biosolutions, LLC (US) 2024-12-25 EP disclosed
WO-2024254156-A1 TREATMENT OF ENDOMETRIAL CANCER WITH MDM2 INHIBITORS KARTOS THERAPEUTICS, INC. (US) 2024-12-12 WO disclosed
EP-4469461-A1 TETRAHYDROPYRANOPYRAZOLE DERIVATIVES FOR THE TREATMENT OF CANCER AND VIRAL INFECTIONS Genase Therapeutics B.V. (NL) 2024-12-04 EP disclosed
EP-4129285-B1 COMPOUNDS FOR USE IN REGULATING FOLLICLE MATURATION UNIV AARHUS (DK) 2024-11-20 EP disclosed
US-12138250-B2 Formulations of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile LOXO ONCOLOGY, INC. (US) 2024-11-12 US disclosed
CN-118946568-A Tetrahydropyranopyrazole derivatives for the treatment of cancer and viral infections 格纳赛治疗有限公司 2024-11-12 CN disclosed
WO-2024229262-A1 NARROW-SPECTRUM ANTIBIOTIC COMPOUNDS AND USES THEREOF MCMASTER UNIVERSITY (CA) 2024-11-07 WO disclosed
US-20240363249-A1 Machine Learning Disease Prediction and Treatment Prioritization AMPEL BIOSOLUTIONS, LLC 2024-10-31 US disclosed
US-20240360135-A1 IMIDAZO[1,2-B]PYRIDAZINYL COMPOUNDS AND USES THEREOF SUMITOMO PHARMA ONCOLOGY INC (US) 2024-10-31 US disclosed
WO-2024217502-A1 METHIONINE ADENOSYLTRANSFERASE 2A (MAT2A) INHIBITOR COMBINATIONS AND USES THEREOF INSILICO MEDICINE IP LIMITED (CN) 2024-10-24 WO disclosed
US-12115153-B2 Methods of treating cancer KARTOS THERAPEUTICS, INC. (US) 2024-10-15 US disclosed
US-20240336977-A1 MICRORNA-REGULATED BIOMARKERS AND DRUG TARGETS FOR IMPROVING DIAGNOSIS AND TREATMENT OF LUNG OR BREAST CANCER West Virginia University Board of Governors on behalf of West Virginia University (US) 2024-10-10 US disclosed
WO-2024211270-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITOR CRYSTALLINE FORM AND USES THEREOF BOUNDLESS BIO, INC. (US) 2024-10-10 WO disclosed
WO-2024211271-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITOR PHARMACEUTICAL COMPOSITION BOUNDLESS BIO, INC. (US) 2024-10-10 WO disclosed
US-20240327435-A1 AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS NUVALENT, INC. 2024-10-03 US disclosed
US-12102621-B2 Formulations of 6-(2-hydroxy-methylpropoxy-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile LOXO ONCOLOGY, INC. (US) 2024-10-01 US disclosed
WO-2024196963-A2 COMPOSITIONS AND METHODS FOR GENOME EDITING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-09-26 WO disclosed
WO-2024196923-A1 USES OF A CHECKPOINT KINASE 1 (CHK1) INHIBITOR BOUNDLESS BIO, INC. (US) 2024-09-26 WO disclosed
US-20240307414-A1 METHODS AND MATERIALS FOR TREATING PROSTATE CANCER MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2024-09-19 US disclosed
WO-2024189607-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT DIDENKO KIRILL (MX) 2024-09-19 WO disclosed
US-20240299558-A1 PROTEOLYSIS TARGETING CHIMERAS AND POLYPHARMACOLOGICAL AGENTS TARGETING BCL-2, AND METHODS OF USE THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-09-12 US disclosed
WO-2024187153-A1 COMPOUNDS TARGETING MUTATIONS IN P53 AND USES THEREOF MERCK SHARP & DOHME LLC (US) 2024-09-12 WO disclosed
US-20240293364-A1 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2024-09-05 US disclosed
CN-118459485-A Amino-substituted heterocycles for the treatment of cancers with EGFR mutations 纽威伦特公司 2024-08-09 CN disclosed
EP-4398903-A1 METHODS OF TREATING CANCER DEPENDENT ON MYC GENE EXPRESSION Kartos Therapeutics (US) 2024-07-17 EP disclosed
EP-4398905-A1 METHODS OF TREATING A CANCER OVEREXPRESSING ONE OR MORE BCL-2 FAMILY PROTEINS Kartos Therapeutics (US) 2024-07-17 EP disclosed
US-12037346-B2 Amino-substituted heteroaryls for treating cancers with EGFR mutations NUVALENT, INC. (US) 2024-07-16 US disclosed
CN-118319866-A Formulations comprising RET kinase inhibitors 罗索肿瘤学公司 2024-07-12 CN disclosed
US-20240228459-A1 WEE1 INHIBITORS AND USES THEREOF BOUNDLESS BIO, INC. 2024-07-11 US disclosed
US-20240216316-A1 DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC BUCK INST RES AGING (US) 2024-07-04 US disclosed
US-20240203555-A1 METHODS AND SYSTEMS FOR THERAPY MONITORING AND TRIAL DESIGN SCIPHER MEDICINE CORP (US) 2024-06-20 US disclosed
US-20240197729-A1 ALK-5 Inhibitors and Uses Thereof SUMITOMO PHARMA ONCOLOGY INC (US) 2024-06-20 US disclosed
WO-2024124240-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS KARTOS THERAPEUTICS (US) 2024-06-13 WO disclosed
EP-4380574-A2 25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR TO AMELIORIATE VASCULAR STIFFNESS Buck Institute for Research on Aging (US) 2024-06-12 EP disclosed
WO-2024118596-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITORS COMBINATIONS AND USES THEREOF BOUNDLESS BIO, INC. (US) 2024-06-06 WO disclosed
WO-2024118564-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF BOUNDLESS BIO, INC. (US) 2024-06-06 WO disclosed
US-11980616-B2 Treating liver disease by selectively eliminating senescent cells MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2024-05-14 US disclosed
US-20240153580-A1 METHODS AND SYSTEMS FOR PERSONALIZED THERAPIES Scipher Medicine Corporation 2024-05-09 US disclosed
US-20240145038-A1 cfDNA FRAGMENTOMIC DETECTION OF CANCER WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2024-05-02 US disclosed
US-11963950-B2 Formulations of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile LOXO ONCOLOGY INC. (US) 2024-04-23 US disclosed
US-11963957-B2 Treating cardiovascular disease by selectively eliminating senescent cells MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2024-04-23 US disclosed
US-11964988-B2 Fused heterocyclic compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2024-04-23 US disclosed
US-20240115563-A1 Treatment of a Senescence-Associated Ocular Disease or Disorder Using a Bcl-xL Selective Inhibitor UNITY BIOTECHNOLOGY, INC. 2024-04-11 US disclosed
US-20240118266-A1 CELL DEATH BIOMARKER UCL BUSINESS PLC (GB) 2024-04-11 US disclosed
EP-4347582-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF Boundless Bio, Inc. (US) 2024-04-10 EP disclosed
US-20240110230-A1 BIOMARKERS FOR CANCER TREATMENT FOUNDATION MEDICINE, INC. (US) 2024-04-04 US disclosed
US-11946094-B2 Combination therapies and methods of use thereof AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) 2024-04-02 US disclosed
US-20240091226-A1 Forms and Formulations Of A Tyrosine Kinase Non-Receptor 1 (TNK1) Inhibitor SUMITOMO PHARMA ONCOLOGY, INC. 2024-03-21 US disclosed
US-20240096469-A1 METHODS OF PREDICTING RESPONSES TO DISEASE TREATMENTS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2024-03-21 US disclosed
CN-117715905-A Checkpoint kinase 1 (CHK 1) inhibitors and uses thereof 无界生物公司 2024-03-15 CN disclosed
US-20240075033-A1 ALK5 INHIBITORS FOR TREATING MYELODYSPLASTIC SYNDROME SUMITOMO PHARMA ONCOLOGY, INC. (US) 2024-03-07 US disclosed
EP-4323356-A1 AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS Nuvalent, Inc. (US) 2024-02-21 EP disclosed
EP-4313052-A1 ALK-5 INHIBITORS AND USES THEREOF Sumitomo Pharma Oncology, Inc. (US) 2024-02-07 EP disclosed
CN-117500803-A Amino-substituted heterocycles for the treatment of cancers with EGFR mutations 纽威伦特公司 2024-02-02 CN disclosed
EP-4301875-A1 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS Otsuka Pharmaceutical Co., Ltd. (JP) 2024-01-10 EP disclosed
US-11865123-B2 Methods of inhibiting pathological angiogenesis UNITY BIOTECHNOLOGY, INC. (US) 2024-01-09 US disclosed
CN-117355304-A ALK-5 inhibitors and uses thereof 住友制药肿瘤公司 2024-01-05 CN disclosed
WO-2024006252-A1 DUAL INHIBITION OF MDM2 AND EIF2-ALPHA INDUCES CELL DEATH IN MULTIPLE CANCER CELL TYPES THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2024-01-04 WO disclosed
US-20230414590-A1 THERAPEUTIC SMALL MOLECULES FOR TREATMENT OF PULMONARY HYPERTENSION THE TEXAS A&M UNIVERSITY SYSTEM 2023-12-28 US disclosed
CN-117295825-A Biomarkers for the treatment of cancer using MDM2 antagonists 大冢制药株式会社 2023-12-26 CN disclosed
EP-4291902-A2 BIOMARKERS FOR CANCER TREATMENT Foundation Medicine, Inc. (US) 2023-12-20 EP disclosed
US-20230398130-A1 METHODS AND COMPOSITIONS FOR DIFFERENTIATING STEM CELLS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2023-12-14 US disclosed
WO-2022221227-A9 AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS NUVALENT, INC. (US) 2023-11-30 WO disclosed
WO-2023230477-A1 PYRIDINE CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF BOUNDLESS BIO, INC. (US) 2023-11-30 WO disclosed
WO-2023225629-A2 METHODS OF GENERATING NATURAL KILLER CELLS FROM PLURIPOTENT STEM CELLS AND COMPOSITIONS THEREOF THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2023-11-23 WO disclosed
EP-4274567-A1 FORMS AND FORMULATIONS OF A TYROSINE KINASE NON-RECEPTOR 1 (TNK1) INHIBITOR Sumitomo Pharma Oncology, Inc. (US) 2023-11-15 EP disclosed
CN-117017987-A Pharmaceutical composition for preventing and treating lung cancer, and preparation method and application thereof 中国人民解放军军事科学院军事医学研究院 2023-11-10 CN disclosed
CN-117017987-A Pharmaceutical composition for preventing and treating lung cancer, and preparation method and application thereof 中国人民解放军军事科学院军事医学研究院 2023-11-10 CN disclosed
WO-2023215756-A2 COMPOSITIONS AND METHODS FOR TREATING PULMONARY VASCULAR DISEASE UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2023-11-09 WO disclosed
US-20230338337-A1 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-10-26 US disclosed
US-11795157-B2 Tetrahydroindazoles and medical uses thereof GENASE THERAPEUTICS B.V. (NL) 2023-10-24 US disclosed
EP-4259145-A1 ALK-5 INHIBITORS AND USES THEREOF Sumitomo Pharma Oncology, Inc. (US) 2023-10-18 EP disclosed
US-11789012-B2 Cell death biomarker UCL BUSINESS LTD (GB) 2023-10-17 US disclosed
US-20230313313-A1 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-10-05 US disclosed
US-20230310423-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF BOUNDLESS BIO, INC. 2023-10-05 US disclosed
WO-2023187599-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR THE TREATMENT OF VIRAL DISEASES DIDENKO KIRILL (MX) 2023-10-05 WO disclosed
CN-116829143-A Forms and formulations of non-receptor tyrosine kinase 1 (TNK 1) inhibitors 住友制药肿瘤公司 2023-09-29 CN disclosed
US-20230293471-A1 USE OF APE1/REF-1 INHIBITORS FOR TREATMENT OF RETINAL DISEASES INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2023-09-21 US disclosed
US-20230285375-A1 COMPOUNDS FOR USE IN REGULATING FOLLICLE MATURATION AARHUS UNIVERSITET (DK) 2023-09-14 US disclosed
US-11746103-B2 ALK-5 inhibitors and uses thereof SUMITOMO PHARMA ONCOLOGY, INC. (US) 2023-09-05 US disclosed
US-20230272485-A1 REPLICATION STRESS PATHWAY AGENT COMPOSITIONS AND METHODS FOR TREATING CANCER BOUNDLESS BIO, INC. 2023-08-31 US disclosed
EP-4232012-A1 METHODS AND COMPOSITIONS FOR DIFFERENTIATING STEM CELLS Massachusetts Institute of Technology (US) 2023-08-30 EP disclosed
EP-4234025-A2 TREATMENT OF DIABETIC RETINOPATHY USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS Unity Biotechnology, Inc. (US) 2023-08-30 EP disclosed
WO-2023158713-A1 UNSUPERVISED MACHINE LEARNING METHODS AMPEL BIOSOLUTIONS, LLC (US) 2023-08-24 WO disclosed
CN-116546986-A ALK-5 inhibitors and uses thereof 住友制药肿瘤公司 2023-08-04 CN disclosed
WO-2023144332-A1 TETRAHYDROPYRANOPYRAZOLE DERIVATIVES FOR THE TREATMENT OF CANCER AND VIRAL INFECTIONS GENASE THERAPEUTICS B.V. (NL) 2023-08-03 WO disclosed
US-11712433-B2 Compositions comprising PKM2 modulators and methods of treatment using the same SUMITOMO PHARMA ONCOLOGY, INC. (US) 2023-08-01 US disclosed
CN-116510024-A Composition, preparation method and application thereof 上海复东生物医药有限责任公司 2023-08-01 CN disclosed
US-20230233557-A1 FORMULATIONS COMPRISING HETEROCYCLIC PROTEIN KINASE INHIBITORS SUMITOMO PHARMA ONCOLOGY, INC. (US) 2023-07-27 US disclosed
US-11707462-B2 Checkpoint kinase 1 (CHK1) inhibitors and uses thereof BOUNDLESS BIO, INC. (US) 2023-07-25 US disclosed
EP-4204812-A2 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS Otsuka Pharmaceutical Co., Ltd. (JP) 2023-07-05 EP disclosed
US-11666561-B2 Compounds for use in regulating follicle maturation AARHUS UNIVERSITET (DK) 2023-06-06 US disclosed
CN-116194088-A Biomarkers for the treatment of cancer using MDM2 antagonists 大冢制药株式会社 2023-05-30 CN disclosed
US-11648226-B2 Use of APE1/Ref-1 inhibitors for treatment of retinal diseases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2023-05-16 US disclosed
EP-3441069-B1 TREATMENT OF DIABETIC RETINOPATHY USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS UNITY BIOTECHNOLOGY INC (US) 2023-04-05 EP disclosed
EP-4157204-A1 DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC Buck Institute for Research on Aging (US) 2023-04-05 EP disclosed
US-20230090742-A1 AMINOPYRIMIDINYLAMINOBENZONITRILE DERIVATIVES AS NEK2 INHIBITORS SUMITOMO PHARMA ONCOLOGY, INC. 2023-03-23 US disclosed
WO-2023039161-A1 METHODS OF TREATING CANCER DEPENDENT ON MYC GENE EXPRESSSION KARTOS THERAPEUTICS (US) 2023-03-16 WO disclosed
WO-2023039160-A1 METHODS OF TREATING A CANCER OVEREXPRESSING ONE OR MORE BCL-2 FAMILY PROTEINS KARTOS THERAPEUTICS (US) 2023-03-16 WO disclosed
US-11603374-B2 Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors ARRAY BIOPHARMA INC. (US) 2023-03-14 US disclosed
EP-3344275-B1 PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF AILERON THERAPEUTICS INC (US) 2023-03-08 EP disclosed
WO-2023014718-A2 25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR TO AMELIORIATE VASCULAR STIFFNESS BUCK INSTITUTE FOR RESEARCH ON AGING (US) 2023-02-09 WO disclosed
EP-4129285-A1 COMPOUNDS FOR USE IN REGULATING FOLLICLE MATURATION Aarhus Universitet (DK) 2023-02-08 EP disclosed
CN-109843333-B Intermediate drug with synergistic anticancer activity and polyethylene glycol coupled synergistic anticancer drug, and preparation method and application thereof 重庆阿普格雷生物科技有限公司 2023-02-03 CN disclosed
US-20230037284-A9 COMBINATION THERAPY OF PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. 2023-02-02 US disclosed
WO-2023010102-A1 IMIDAZO[1,2-B]PYRIDAZINYL COMPOUNDS AND USES THEREOF SUMITOMO PHARMA ONCOLOGY, INC. (US) 2023-02-02 WO disclosed
US-20230027472-A1 TARGETING P73 FOR CANCERS RESISTANT TO BH3 MIMETICS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-01-26 US disclosed
US-20230026313-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF BOUNDLESS BIO, INC. 2023-01-26 US disclosed
WO-2022266491-A1 PROTEOLYSIS TARGETING CHIMERAS AND POLYPHARMACOLOGICAL AGENTS TARGETING BCL-2, AND METHODS OF USE THEREOF UNIVERSITY OF MARYLAND, BALTIMORE (US) 2022-12-22 WO disclosed
US-11529350-B2 Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof SUMITOMO PHARMA ONCOLOGY, INC. (US) 2022-12-20 US disclosed
US-11524963-B2 Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2022-12-13 US disclosed
WO-2022251502-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF BOUNDLESS BIO, INC. (US) 2022-12-01 WO disclosed
US-20220363696-A1 AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS NUVALENT, INC. 2022-11-17 US disclosed
US-20220347277-A1 Methods to Enhance Tumor Immunogenicity and Compositions for Autologous Cancer Immunotherapeutic Products Using Modified Tumor Cells and Modified Dendritic Cells AIVITA BIOMEDICAL INC (US) 2022-11-03 US disclosed
EP-4081801-A2 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS Otsuka Pharmaceutical Co., Ltd. (JP) 2022-11-02 EP disclosed
US-11484600-B2 Intermediate drug with synergistic anticancer activity and polyethylene glycol-coupled synergistic anticancer drug, and preparation method therefor and use thereof Chongqing Upgra Biotechnology Co., Ltd. (CN) 2022-11-01 US disclosed
US-11478469-B2 Combination product of BCL-2 inhibitor and MDM2 inhibitor and use thereof in the prevention and/or treatment of diseases ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) 2022-10-25 US disclosed
WO-2022221227-A1 AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS NUVALENT, INC. (US) 2022-10-20 WO disclosed
US-11471456-B2 Formulations comprising heterocyclic protein kinase inhibitors SUMITOMO PHARMA ONCOLOGY, INC. (US) 2022-10-18 US disclosed
US-11472802-B2 Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2022-10-18 US disclosed
US-11471462-B2 Compositions and methods for detecting and treating diabetes THE BROAD INSTITUTE, INC. (US) 2022-10-18 US disclosed
US-20220323406-A1 METHODS AND COMPOSITIONS FOR DIFFERENTIATING STEM CELLS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-10-13 US disclosed
CN-111615514-B Substituted pyrazolo [4,3-C ] pyridine compounds as RET kinase inhibitors 奥瑞生物药品公司 2022-10-11 CN disclosed
US-20220315563-A1 ALK-5 INHIBITORS AND USES THEREOF SUMITOMO PHARMA ONCOLOGY, INC. 2022-10-06 US disclosed
WO-2022204721-A1 ALK-5 INHIBITORS AND USES THEREOF SUMITOMO PHARMA ONCOLOGY, INC. (US) 2022-09-29 WO disclosed
US-20220305008-A1 TREATMENT OF CANCER HAVING GNAQ OR GNA11 GENETIC MUTATIONS WITH PROTEIN KINASE C INHIBITORS IDEAYA BIOSCIENCES, INC. 2022-09-29 US disclosed
CN-115066614-A Biomarkers for treating cancer using MDM2 antagonists 大冢制药株式会社 2022-09-16 CN disclosed
WO-2022185260-A1 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2022-09-09 WO disclosed
WO-2022174234-A2 BIOMARKERS FOR CANCER TREATMENT FOUNDATION MEDICINE, INC. (US) 2022-08-18 WO disclosed
US-20220241316-A1 25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR, IS A NOVEL SENOLYTIC BUCK INSTITUTE FOR RESEARCH ON AGING (US) 2022-08-04 US disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 US disclosed
US-20220244244-A1 A GENETIC PHARMACOPEIA FOR COMPREHENSIVE FUNCTIONAL PROFILING OF HUMAN CANCERS FUNCTION ONCOLOGY, INC. 2022-08-04 US disclosed
EP-3630106-B1 COMPOUNDS FOR USE IN REGULATING FOLLICLE MATURATION UNIV AARHUS (DK) 2022-07-27 EP disclosed
WO-2022150801-A1 FORMS AND FORMULATIONS OF A TYROSINE KINASE NON-RECEPTOR 1 (TNK1) INHIBITOR SUMITOMO PHARMA ONCOLOGY, INC. (US) 2022-07-14 WO disclosed
US-20220202788-A1 FORMULATIONS OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6-DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE LOXO ONCOLOGY, INC. 2022-06-30 US disclosed
US-20220186321-A1 PROGNOSIS METHOD OF CANCER CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2022-06-16 US disclosed
WO-2022126133-A1 ALK-5 INHIBITORS AND USES THEREOF SUMITOMO PHARMA ONCOLOGY,INC. (US) 2022-06-16 WO disclosed
EP-3849986-B1 FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2022-06-08 EP disclosed
US-11351167-B2 Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissue BUCK INSTITUTE FOR RESEARCH ON AGING (US) 2022-06-07 US disclosed
US-20220162200-A1 PKM2 MODULATORS AND METHODS FOR THEIR USE SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. 2022-05-26 US disclosed
WO-2022103706-A1 THERAPEUTIC SMALL MOLECULES FOR TREATMENT OF PULMONARY HYPERTENSION UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2022-05-19 WO disclosed
EP-3994132-A1 TYROSINE KINASE NON-RECEPTOR 1 (TNK1) INHIBITORS AND USES THEREOF Sumitomo Dainippon Pharma Oncology, Inc. (US) 2022-05-11 EP disclosed
US-11324827-B2 Multifunctionalized polyethylene glycol derivative and preparation method therefor XIAMEN SINOPEG BIOTECH CO., LTD. (CN) 2022-05-10 US disclosed
WO-2022087526-A1 METHODS AND COMPOSITIONS FOR DIFFERENTIATING STEM CELLS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-04-28 WO disclosed
US-20220112214-A1 FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2022-04-14 US disclosed
CN-114302878-A Tyrosine kinase non-receptor 1(TNK1) inhibitors and uses thereof 大日本住友制药肿瘤公司 2022-04-08 CN disclosed
US-20220096466-A1 TREATMENT OF PARKINSON'S DISEASE AND OTHER CONDITIONS CAUSED OR MEDIATED BY SENESCENT ASTROCYTES USING SMALL MOLECULE SENOLYTIC AGENTS MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2022-03-31 US disclosed
EP-3974424-A1 TETRAHYDROINDAZOLES AND MEDICAL USES THEREOF Genase Therapeutics B.V. (NL) 2022-03-30 EP disclosed
EP-3669881-B1 COMPOSITIONS FOR USE IN THE TREATMENT OF SENESCENCE-ASSIOCATED EYE DISEASE AND DISORDERS BUCK INST RES AGING (US) 2022-03-30 EP disclosed
US-20220087988-A1 FORMULATIONS OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6-DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE LOXO ONCOLOGY, INC. 2022-03-24 US disclosed
CN-108348571-B Peptidomimetic macrocycles and uses thereof 艾瑞朗医疗公司 2022-03-22 CN disclosed
US-20220081438-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES ARRAY BIOPHARMA INC. 2022-03-17 US disclosed
US-20220072015-A1 Methods of Inhibiting Pathological Angiogenesis UNITY BIOTECHNOLOGY, INC. 2022-03-10 US disclosed
WO-2022043930-A2 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2022-03-03 WO disclosed
EP-3955916-A1 25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR, IS A NOVEL SENOLYTIC Buck Institute for Research on Aging (US) 2022-02-23 EP disclosed
US-20220040166-A1 Methods and Compositions of Treating an Ophthalmic Condition KARTOS THERAPEUTICS (US) 2022-02-10 US disclosed
EP-3947736-A1 PROGNOSIS METHOD OF CANCER Centre national de la recherche scientifique (FR) 2022-02-09 EP disclosed
US-20220031694-A1 COMBINATION PRODUCT OF BCL-2 INHIBITOR AND MDM2 INHIBITOR AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) 2022-02-03 US disclosed
US-20220031694-A1 COMBINATION PRODUCT OF BCL-2 INHIBITOR AND MDM2 INHIBITOR AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) 2022-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (50 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240197729-A1 ALK-5 Inhibitors and Uses Thereof ACVR1, ALK, ACVRL1 HRH3 2347/4885HTR2A 3822/4885HTR1A 3104/4885
US-20250127777-A1 DUAL INHIBITION OF MDM2 AND EIF2-ALPHA INDUCES CELL DEATH IN MULTIPLE CANCER CELL TYPES EIF2AK1, EIF2AK2, EEF2K HRH3 4326/4885HTR2A 3747/4885HTR1A 4648/4885
US-20240293364-A1 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS MSH2, MRE11, RAD50 HRH3 716/4885HTR2A 1352/4885HTR1A 1772/4885
US-11963957-B2 Treating cardiovascular disease by selectively eliminating senescent cells GLA, MMP13, MMP11 HRH3 4602/4885HTR2A 4293/4885HTR1A 4414/4885
US-20250387383-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS JAK2, JAK1, MPL HRH3 2961/4885HTR2A 4274/4885HTR1A 4108/4885
US-20230346879-A1 COMPOSITIONS AND METHODS FOR COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS RAB5IF, CLTB, TBK1 HRH3 3911/4885HTR2A 4787/4885HTR1A 4851/4885
US-20220072015-A1 Methods of Inhibiting Pathological Angiogenesis VEGFA, FLT1, FLT4 HRH3 2828/4885HTR2A 3669/4885HTR1A 3335/4885
US-12037346-B2 Amino-substituted heteroaryls for treating cancers with EGFR mutations EGFR, ERBB2, ERBB3 HRH3 1550/4885HTR2A 1269/4885HTR1A 1492/4885
US-20230313313-A1 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS SKP2, MDM2, TP53 HRH3 3521/4885HTR2A 3607/4885HTR1A 3957/4885
US-20230310423-A1 CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF CHEK1, CHEK2, RAD1 HRH3 2078/4885HTR2A 4678/4885HTR1A 4522/4885
US-11484600-B2 Intermediate drug with synergistic anticancer activity and polyethylene glycol-coupled synergistic anticancer drug, and preparation method therefor and use thereof WEE1, WEE2, SLC11A2 HRH3 4761/4885HTR2A 4795/4885HTR1A 4464/4885
US-20220202788-A1 FORMULATIONS OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6-DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE RET, ALK, BRAF HRH3 355/4885HTR2A 706/4885HTR1A 505/4885
US-12115153-B2 Methods of treating cancer VHL, MDM2, TP53 HRH3 4256/4885HTR2A 4248/4885HTR1A 4181/4885
US-11529350-B2 Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof TNK1, TNNI3K, TYK2 HRH3 627/4885HTR2A 1903/4885HTR1A 969/4885
US-11707462-B2 Checkpoint kinase 1 (CHK1) inhibitors and uses thereof CHEK1, CHEK2, RAD1 HRH3 2078/4885HTR2A 4678/4885HTR1A 4522/4885
US-11865123-B2 Methods of inhibiting pathological angiogenesis VEGFA, FLT1, FLT4 HRH3 2828/4885HTR2A 3669/4885HTR1A 3335/4885
US-12268681-B2 Methods of treating myeloproliferative neoplasms JAK2, JAK1, PDPK1 HRH3 2932/4885HTR2A 3698/4885HTR1A 3702/4885
US-11980616-B2 Treating liver disease by selectively eliminating senescent cells GLA, MMP13, MMP11 HRH3 4349/4885HTR2A 4480/4885HTR1A 4542/4885
US-20250288572-A1 COMPOSITIONS AND METHODS FOR TREATING PULMONARY VASCULAR DISEASE GLUL, GGT1, GLS HRH3 4459/4885HTR2A 4832/4885HTR1A 4453/4885
US-20230090742-A1 AMINOPYRIMIDINYLAMINOBENZONITRILE DERIVATIVES AS NEK2 INHIBITORS NEK4, NEK2, NEK1 HRH3 1470/4885HTR2A 3724/4885HTR1A 4550/4885
US-11712433-B2 Compositions comprising PKM2 modulators and methods of treatment using the same PDK1, PDK2, PKM HRH3 4705/4885HTR2A 4267/4885HTR1A 4586/4885
US-20240299558-A1 PROTEOLYSIS TARGETING CHIMERAS AND POLYPHARMACOLOGICAL AGENTS TARGETING BCL-2, AND METHODS OF USE THEREOF BCL3, MCL1, BCL2 HRH3 3817/4885HTR2A 3269/4885HTR1A 4409/4885
US-20220087988-A1 FORMULATIONS OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6-DIAZABICYCLO[3.1.1]HEPTAN-3-YL)PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE RET, ALK, BRAF HRH3 355/4885HTR2A 706/4885HTR1A 505/4885
US-20220162200-A1 PKM2 MODULATORS AND METHODS FOR THEIR USE PDK1, PKM, PDK2 HRH3 3433/4885HTR2A 2472/4885HTR1A 2645/4885
US-11963950-B2 Formulations of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile RET, ALK, BRAF HRH3 355/4885HTR2A 706/4885HTR1A 505/4885
US-20260097028-A1 Methods of Treating Myeloproliferative Neoplasms JAK2, TP53, CDKN1A HRH3 3343/4885HTR2A 4075/4885HTR1A 4080/4885
US-20220096466-A1 TREATMENT OF PARKINSON'S DISEASE AND OTHER CONDITIONS CAUSED OR MEDIATED BY SENESCENT ASTROCYTES USING SMALL MOLECULE SENOLYTIC AGENTS SNCA, SENP3, SENP2 HRH3 3134/4885HTR2A 1430/4885HTR1A 2455/4885
US-20250134876-A1 METHODS OF TREATING A CANCER OVEREXPRESSING ONE OR MORE BCL-2 FAMILY PROTEINS BCL2, BCL2L2, BCL2L1 HRH3 4603/4885HTR2A 2325/4885HTR1A 3858/4885
US-12595515-B2 Prognosis method of cancer DDIT3, UPF1, MKI67 HRH3 4795/4885HTR2A 3403/4885HTR1A 3607/4885
US-20250090517-A1 Methods of Treating Cancer VHL, MDM2, TP53 HRH3 4256/4885HTR2A 4248/4885HTR1A 4181/4885
US-12599592-B2 Therapeutic small molecules for treatment of pulmonary hypertension GSTP1, GSTK1, GSTM1 HRH3 1200/4885HTR2A 3114/4885HTR1A 2519/4885
US-20230338337-A1 BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS IRF2BP2, BST2, IRF3 HRH3 2783/4885HTR2A 2491/4885HTR1A 2882/4885
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US-20230233557-A1 FORMULATIONS COMPRISING HETEROCYCLIC PROTEIN KINASE INHIBITORS PIM1, GK, PIM2 HRH3 3094/4885HTR2A 4302/4885HTR1A 4598/4885
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“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.