Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131433 | 0.85 | HIF1A (0.46) | CHRNB2CHRNA4LMNAALDH1A1CYP2D6 | |
| SCHEMBL4747138 | 0.84 | CHRM2 (0.63) | LMNAALDH1A1CYP2D6CYP1A2OPRK1 | |
| SCHEMBL12888668 | 0.83 | CHRNB2 (0.67) | CHRNB2CHRNA4LMNAALDH1A1CYP2D6 | |
| SCHEMBL5247888 | 0.77 | POLB (0.53) | CHRNB2CHRNA4LMNAALDH1A1CYP2D6 | |
| SCHEMBL14220155 | 0.77 | MEN1 (0.56) | LMNAALDH1A1CYP2D6CYP1A2OPRK1 | |
| SCHEMBL11767989 | 0.76 | CYP2D6 (0.46) | CHRNB2CHRNA4LMNAALDH1A1CYP2D6 | |
| SCHEMBL9447012 | 0.75 | HIF1A (0.49) | LMNAALDH1A1CYP2D6CYP1A2OPRK1 | |
| SCHEMBL6184529 | 0.75 | HIF1A (0.49) | LMNAALDH1A1CYP2D6CYP1A2OPRK1 | |
| SCHEMBL3460939 | 0.75 | CHRNB2 (1.00) | CHRNB2CHRNA4LMNAALDH1A1CYP2D6 | |
| SCHEMBL30632262 | 0.75 | CHRNB2 (1.00) | CHRNB2CHRNA4LMNAALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |