Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 3/20 | 0.68 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | JUN | P05412 | 1/20 | 0.59 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805635 | 1.00 | MAPT (0.68) | MAPTKMT2AMAPK1MEN1TP53 | |
| SCHEMBL8806767 | 0.84 | MAPT (0.76) | MAPTKMT2AMAPK1MEN1TP53 | |
| SCHEMBL8806771 | 0.84 | MAPT (0.76) | MAPTKMT2AMAPK1MEN1TP53 | |
| SCHEMBL861728 | 0.81 | MAPT (1.00) | MAPTKMT2AMAPK1MEN1TP53 | |
| SCHEMBL861729 | 0.81 | MAPT (1.00) | MAPTKMT2AMAPK1MEN1TP53 | |
| SCHEMBL196640 | 0.78 | PFKFB3 (1.00) | MAPTKMT2AMAPK1PFKFB3CYP3A4 | |
| SCHEMBL29458617 | 0.78 | PFKFB3 (1.00) | MAPTKMT2AMAPK1PFKFB3CYP3A4 | |
| SCHEMBL196639 | 0.78 | PFKFB3 (1.00) | MAPTKMT2AMAPK1PFKFB3CYP3A4 | |
| SCHEMBL13479662 | 0.78 | RAB9A (0.88) | MAPTKMT2AMAPK1PFKFB3CYP3A4 | |
| SCHEMBL5598850 | 0.76 | MAPT (1.00) | MAPTKMT2AMAPK1PFKFB3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0476646-B1 | Calcium uptake inhibitors | MERRELL PHARMA INC (US) | 1997-06-04 | — | — | EP | claimed |
| EP-0476646-A1 | Calcium uptake inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-03-25 | — | — | EP | claimed |
| JP-6271540-A | — | — | None | — | — | JP | disclosed |
| EP-0476646-B1 | Calcium uptake inhibitors | MERRELL PHARMA INC (US) | 1997-06-04 | — | — | EP | disclosed |
| US-5500429-A | CARDIOVASCULAR | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-19 | — | — | US | disclosed |
| JP-H06271540-A | CALCIUM UPTAKE INHIBITOR | MERRELL DOW PHARMACEUT INC | 1994-09-27 | — | — | JP | disclosed |
| EP-0476646-A1 | Calcium uptake inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-03-25 | — | — | EP | disclosed |