Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8806985 | 0.94 | ABCB1 (0.42) | ABCB1ABCG2MAPK1TP53RXFP1 | |
| SCHEMBL8807343 | 0.92 | ABCB1 (0.42) | ABCB1ABCG2MAPK1KDM4EALDH1A1 | |
| SCHEMBL8806933 | 0.92 | KDM4E (0.42) | ABCB1ABCG2LMNAMAPK1KDM4E | |
| SCHEMBL8807986 | 0.90 | KCNH2 (0.41) | ABCB1ABCG2LMNAMAPK1KDM4E | |
| SCHEMBL8806990 | 0.90 | ABCG2 (0.39) | ABCB1ABCG2LMNAMAPK1KDM4E | |
| SCHEMBL8807015 | 0.90 | ABCG2 (0.44) | ABCB1ABCG2LMNASMPD1KDM4E | |
| SCHEMBL8807354 | 0.88 | ABCG2 (0.40) | ABCB1ABCG2LMNAMAPK1KDM4E | |
| SCHEMBL8808386 | 0.88 | MAPT (0.45) | ABCB1ABCG2LMNASMPD1KDM4E | |
| SCHEMBL8806941 | 0.87 | ABCG2 (0.40) | ABCB1ABCG2LMNAMAPK1KDM4E | |
| SCHEMBL8809566 | 0.86 | BCHE (0.43) | ABCB1ABCG2LMNAMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |