Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807068 | 0.92 | KCNH2 (0.44) | KCNH2KDRMAPK1LMNADRD2 | |
| SCHEMBL8806058 | 0.90 | ABCB1 (0.43) | MAPK1LMNAABCG2ABCB1KDM4E | |
| SCHEMBL8806933 | 0.89 | KDM4E (0.42) | MAPK1LMNAABCG2ABCB1KDM4E | |
| SCHEMBL8808236 | 0.88 | MAPT (0.45) | KCNH2KDRLMNAABCG2ABCB1 | |
| SCHEMBL8810117 | 0.85 | MCHR1 (0.45) | KDRMAPK1DRD2DRD3HRH3 | |
| SCHEMBL8808386 | 0.85 | MAPT (0.45) | LMNAABCG2ABCB1KDM4EALDH1A1 | |
| SCHEMBL8807343 | 0.85 | ABCB1 (0.42) | MAPK1ABCG2ABCB1KDM4EALDH1A1 | |
| SCHEMBL8806941 | 0.85 | ABCG2 (0.40) | MAPK1LMNAABCG2ABCB1MAOB | |
| SCHEMBL8806985 | 0.84 | ABCB1 (0.42) | MAPK1ABCG2ABCB1TP53RXFP1 | |
| SCHEMBL8807995 | 0.84 | MAOA (0.39) | KCNH2KDRMAPK1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |