Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807068 | 0.96 | KCNH2 (0.44) | MAPTKDM4ECYP3A4CYP2C19TP53 | |
| SCHEMBL8808363 | 0.93 | MAOA (0.46) | KDRMAOAMAOB | |
| SCHEMBL8807015 | 0.92 | ABCG2 (0.44) | MAPTKDM4ECYP3A4CYP2C19TP53 | |
| SCHEMBL8808386 | 0.92 | MAPT (0.45) | MAPTKDM4ECYP3A4CYP2C19ABCG2 | |
| SCHEMBL8810117 | 0.89 | MCHR1 (0.45) | MAPTKDM4ETP53KDRMAOA | |
| SCHEMBL8807986 | 0.88 | KCNH2 (0.41) | MAPTKDM4ECYP3A4CYP2C19TP53 | |
| SCHEMBL8807951 | 0.88 | BCHE (0.45) | MAPTKDM4ECYP3A4ABCG2LMNA | |
| SCHEMBL8808371 | 0.87 | KDR (0.46) | MAPTKDM4ETP53KDRMAOA | |
| SCHEMBL8809632 | 0.86 | BCHE (0.44) | MAPTKDM4ECYP3A4TP53MAOB | |
| SCHEMBL8808197 | 0.86 | ABCG2 (0.46) | MAPTKDM4ETP53TDP1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |