Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.67 |
| ▸ | PPARA | Q07869 | 17/20 | 0.67 |
| ▸ | PPARD | Q03181 | 8/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807261 | 1.00 | PPARG (0.67) | PPARGPPARAPPARD | |
| SCHEMBL14382157 | 0.88 | PPARG (0.69) | PPARGPPARAPPARD | |
| SCHEMBL12652544 | 0.88 | PPARG (0.69) | PPARGPPARAPPARD | |
| SCHEMBL6963111 | 0.86 | PPARG (0.67) | PPARGPPARAPPARD | |
| SCHEMBL6963103 | 0.86 | PPARG (0.67) | PPARGPPARAPPARD | |
| SCHEMBL4746469 | 0.86 | PPARG (0.73) | PPARGPPARAPPARD | |
| SCHEMBL13722003 | 0.86 | PPARG (0.69) | PPARGPPARAPPARD | |
| SCHEMBL7165258 | 0.85 | PPARG (0.69) | PPARGPPARAPPARD | |
| SCHEMBL8846002 | 0.85 | PPARG (0.72) | PPARGPPARAPPARD | |
| SCHEMBL8845995 | 0.85 | PPARG (0.72) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533781-B1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5438074-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1995-08-01 | — | — | US | disclosed |
| US-5306726-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1994-04-26 | — | — | US | disclosed |
| US-5232945-A | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0533781-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| US-5089514-A | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| WO-1991019702-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |