Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.67 |
| ▸ | KDR | P35968 | 6/20 | 0.67 |
| ▸ | RET | P07949 | 2/20 | 0.67 |
| ▸ | LCK | P06239 | 3/20 | 0.66 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.63 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | STK10 | O94804 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807988 | 0.96 | EGFR (0.67) | EGFRKDRRETLCKLRRK2 | |
| SCHEMBL8807167 | 0.86 | EGFR (0.75) | EGFRKDRRETLCKLRRK2 | |
| SCHEMBL14982743 | 0.84 | LRRK2 (0.84) | EGFRKDRRETLCKLRRK2 | |
| SCHEMBL18158179 | 0.83 | EGFR (0.79) | EGFRKDRRETLCKPIK3CD | |
| Hydrochloric Acid SCHEMBL8810155 | 0.82 | EGFR (0.79) | EGFRKDRRETLCKPIK3CD | |
| Hydrochloric Acid SCHEMBL8811415 | 0.82 | EGFR (0.79) | EGFRKDRRETLCKPIK3CD | |
| SCHEMBL1387182 | 0.82 | EGFR (0.94) | EGFRKDRRETLCKRIPK2 | |
| SCHEMBL29515328 | 0.82 | EGFR (1.00) | EGFRKDRRETLCKRIPK2 | |
| SCHEMBL1257431 | 0.82 | EGFR (1.00) | EGFRKDRRETLCKRIPK2 | |
| SCHEMBL8306414 | 0.81 | LRRK2 (0.82) | EGFRKDRRETLCKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782570-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009294-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |