Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | UBE2M | P61081 | 5/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807180 | 0.92 | GAA (0.49) | GAANPSR1KMT2AMEN1UBE2M | |
| SCHEMBL8809108 | 0.91 | GAA (0.48) | GAANPSR1UBE2MDCUN1D1TP53 | |
| SCHEMBL8810779 | 0.90 | NPSR1 (0.47) | GAANPSR1KMT2AUBE2MDCUN1D1 | |
| SCHEMBL8809508 | 0.90 | TP53 (0.50) | GAANPSR1KMT2AMEN1UBE2M | |
| SCHEMBL9057173 | 0.89 | TP53 (0.51) | GAANPSR1KMT2AMEN1UBE2M | |
| SCHEMBL8807322 | 0.88 | GAA (0.46) | GAANPSR1KMT2AMEN1UBE2M | |
| SCHEMBL8810238 | 0.88 | KMT2A (0.41) | GAANPSR1KMT2AMEN1UBE2M | |
| SCHEMBL8807262 | 0.85 | HTR2C (0.44) | GAANPSR1KMT2AMEN1UBE2M | |
| SCHEMBL8810538 | 0.85 | GAA (0.43) | GAANPSR1KMT2AUBE2MDCUN1D1 | |
| SCHEMBL9057006 | 0.85 | LMNA (0.49) | GAANPSR1UBE2MDCUN1D1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |