Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807135 | 0.81 | ALOX5 (1.00) | ALOX5 | |
| SCHEMBL8807487 | 0.78 | ALOX5 (0.69) | ALOX5 | |
| SCHEMBL8806923 | 0.77 | ALOX5 (0.73) | ALOX5 | |
| SCHEMBL8933773 | 0.76 | ALOX5 (1.00) | ALOX5 | |
| SCHEMBL2396418 | 0.76 | ALOX5 (0.63) | ALOX5 | |
| SCHEMBL10480439 | 0.76 | ALOX5 (0.63) | ALOX5 | |
| Ammonia Solution, Strong SCHEMBL9473339 | 0.75 | ALOX5 (0.97) | ALOX5 | |
| SCHEMBL9475019 | 0.75 | ALOX5 (0.97) | ALOX5 | |
| SCHEMBL9474724 | 0.75 | ALOX5 (0.97) | ALOX5 | |
| SCHEMBL9473677 | 0.72 | ALOX5 (0.66) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320628-B1 | Substituted furan compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5112848-A | Antiasthmatics and antiarthritic agents | ABBOTT LABORATORIES (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0388429-A4 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0388429-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-09-26 | — | — | EP | disclosed |
| EP-0320628-A1 | Substituted furan compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase | ABBOTT LABORATORIES (US) | 1989-06-21 | — | — | EP | disclosed |
| WO-1989004299-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-05-18 | — | — | WO | disclosed |