Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 4/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.52 |
| ▸ | TTR | P02766 | 3/20 | 0.52 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 6/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808590 | 1.00 | PARP1 (0.54) | PARP1PIM1PIM2TTRCISD1 | |
| SCHEMBL8808594 | 0.89 | PARP1 (0.42) | PARP1PIM1PIM2TTRCISD1 | |
| SCHEMBL8809653 | 0.86 | TTR (0.54) | PARP1PIM1PIM2TTRMEN1 | |
| SCHEMBL8685838 | 0.86 | TTR (0.54) | PARP1PIM1PIM2TTRMEN1 | |
| SCHEMBL8686827 | 0.83 | PARP1 (0.52) | PARP1PIM1PIM2TTRMEN1 | |
| SCHEMBL8808598 | 0.83 | PARP1 (0.52) | PARP1PIM1PIM2TTRMEN1 | |
| SCHEMBL8811258 | 0.81 | MEN1 (0.54) | PARP1PIM1PIM2TTRPTPN1 | |
| SCHEMBL8685694 | 0.81 | MEN1 (0.54) | PARP1PIM1PIM2TTRPTPN1 | |
| SCHEMBL3623386 | 0.79 | HTR6 (0.51) | HTR6 | |
| SCHEMBL3613851 | 0.78 | HTR6 (0.48) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |