Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 11/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808586 | 0.89 | PARP1 (0.54) | PARP1HTR6TTRPIM1CISD1 | |
| SCHEMBL8808590 | 0.89 | PARP1 (0.54) | PARP1HTR6TTRPIM1CISD1 | |
| SCHEMBL8810801 | 0.86 | HDAC3 (0.50) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8808603 | 0.83 | HTR6 (0.44) | PARP1HTR6HDAC3HDAC4HDAC1 | |
| SCHEMBL3623386 | 0.79 | HTR6 (0.51) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3613851 | 0.78 | HTR6 (0.48) | HTR6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8811389 | 0.78 | PARP1 (0.62) | PARP1TTRPIM1CISD1PIM2 | |
| SCHEMBL8811331 | 0.75 | KDM4E (0.48) | HTR6MAPTHTT | |
| SCHEMBL8812036 | 0.75 | PARP1 (0.54) | PARP1TTRPIM1CISD1PIM2 | |
| SCHEMBL8813331 | 0.74 | PARP1 (0.47) | PARP1TTRPIM1CISD1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |