Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | DRD4 | P21917 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808946 | 1.00 | HTR1A (0.75) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL9325431 | 0.94 | HTR1A (0.67) | HTR1ASLC6A4 | |
| SCHEMBL9325424 | 0.94 | HTR1A (0.67) | HTR1ASLC6A4 | |
| SCHEMBL9326949 | 0.91 | SLC6A4 (0.72) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL8814536 | 0.91 | SLC6A4 (0.72) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL8812106 | 0.89 | HTR1A (0.71) | HTR1ASLC6A4 | |
| SCHEMBL8815142 | 0.89 | SLC6A4 (0.71) | HTR1ASLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL8812113 | 0.89 | HTR1A (0.71) | HTR1ASLC6A4 | |
| SCHEMBL8811506 | 0.89 | HTR1A (0.68) | HTR1ASLC6A4 | |
| SCHEMBL8809960 | 0.89 | SLC6A4 (0.69) | HTR1ASLC6A4ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646112-A4 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS. | ABBOTT LAB (US) | 1997-04-02 | — | — | EP | claimed |
| EP-0646112-A1 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1995-04-05 | — | — | EP | claimed |
| WO-1993012754-A2 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1993-07-08 | — | — | WO | claimed |
| EP-0646112-A4 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS. | ABBOTT LAB (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0646112-A1 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1995-04-05 | — | — | EP | disclosed |
| US-5288749-A | Treating central nervous system or cardiovascular disorders | ABBOTT LABORATORIES (US) | 1994-02-22 | — | — | US | disclosed |
| WO-1993012754-A2 | TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS | ABBOTT LABORATORIES (US) | 1993-07-08 | — | — | WO | disclosed |