Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809339 | 0.98 | EDNRA (0.44) | EDNRAACEHRH4ALDH1A1MAPT | |
| SCHEMBL8809676 | 0.89 | EDNRA (0.41) | EDNRAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL8807025 | 0.87 | EDNRA (0.41) | EDNRAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL8807936 | 0.86 | TACR1 (0.45) | SMN1; SMN2MAPK1 | |
| SCHEMBL8809202 | 0.86 | EDNRA (0.40) | EDNRAACEALDH1A1MAPTLMNA | |
| SCHEMBL8809473 | 0.84 | TACR1 (0.45) | SMN1; SMN2MAPK1 | |
| SCHEMBL8807087 | 0.83 | EDNRA (0.42) | EDNRAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL8810904 | 0.81 | TACR1 (0.46) | SMN1; SMN2MAPK1 | |
| SCHEMBL8809610 | 0.80 | EDNRA (0.44) | EDNRAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL8807991 | 0.80 | MAPK1 (0.43) | ACESMN1; SMN2POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |