Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.34 |
| ▸ | PTGFR | P43088 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807025 | 0.97 | EDNRA (0.41) | EDNRAAKR1C3AKR1C2MAPK9TGFBR1 | |
| SCHEMBL8807087 | 0.94 | EDNRA (0.42) | EDNRAAKR1C3AKR1C2MAPK9TGFBR1 | |
| SCHEMBL8809610 | 0.91 | EDNRA (0.44) | EDNRAAKR1C3AKR1C2MAPK9CYP1A2 | |
| SCHEMBL8809082 | 0.89 | EDNRA (0.44) | EDNRATGFBR1ALDH1A1LMNAMAPT | |
| SCHEMBL8809339 | 0.87 | EDNRA (0.44) | EDNRATGFBR1ALDH1A1LMNAMAPT | |
| SCHEMBL8810101 | 0.84 | IL6ST (0.36) | EDNRATGFBR1KMT2AALDH1A1EDNRB | |
| SCHEMBL8807991 | 0.84 | MAPK1 (0.43) | KMT2ASMN1; SMN2 | |
| SCHEMBL8809374 | 0.83 | EDNRA (0.40) | EDNRAALDH1A1LMNAMAPTMME | |
| SCHEMBL8811832 | 0.82 | IL6ST (0.35) | EDNRAALDH1A1EDNRBLMNAMAPT | |
| SCHEMBL8807936 | 0.79 | TACR1 (0.45) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |