Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | IL1RN | P18510 | 1/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809374 | 0.93 | EDNRA (0.40) | EDNRACTSSCTSKACEALDH1A1 | |
| SCHEMBL8809473 | 0.91 | TACR1 (0.45) | TACR1IL1RNERAP2MAPK1 | |
| SCHEMBL8807936 | 0.89 | TACR1 (0.45) | TACR1IL1RNERAP2MAPK1 | |
| SCHEMBL8809339 | 0.88 | EDNRA (0.44) | EDNRAACEALDH1A1LMNAMAPT | |
| SCHEMBL8810904 | 0.87 | TACR1 (0.46) | TACR1IL1RNERAP2MAPK1 | |
| SCHEMBL8809082 | 0.86 | EDNRA (0.44) | EDNRAACEALDH1A1LMNAMAPT | |
| SCHEMBL8807044 | 0.85 | TACR1 (0.47) | TACR1IL1RNERAP2ALDH1A1LMNA | |
| SCHEMBL8807036 | 0.85 | SMN1; SMN2 (0.43) | EDNRATACR1CTSSCTSKLMNA | |
| SCHEMBL8810295 | 0.84 | MAPK1 (0.44) | CTSSCTSKACEPOLBMAPK1 | |
| SCHEMBL8807991 | 0.83 | MAPK1 (0.43) | CTSSCTSKACEPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |