Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL502548 | 0.80 | SRC (0.47) | BRPF1ALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL502110 | 0.78 | SRC (0.51) | BRPF1ALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL854684 | 0.76 | SRC (0.44) | BRPF1ALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL12992386 | 0.76 | BRPF1 (0.75) | BRPF1KDM4EALDH1A1HSD17B10RAB9A | |
| SCHEMBL19448891 | 0.75 | BRPF1 (0.54) | BRPF1KDM4EALDH1A1HSD17B10TP53 | |
| SCHEMBL11826135 | 0.72 | BRPF1 (0.47) | BRPF1KDM4EALDH1A1HSD17B10NPC1 | |
| SCHEMBL30092397 | 0.69 | PLA2G7 (0.65) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL8848693 | 0.69 | PLA2G7 (0.65) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL31607621 | 0.69 | PLA2G7 (0.65) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL24885903 | 0.69 | SRC (0.58) | RAF1FGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252612-B1 | HETEROCYCLIC COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS | IRM LLC (BM) | 2012-03-28 | — | — | EP | disclosed |