Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | ESRRG | P62508 | 4/20 | 0.46 |
| ▸ | ESRRB | O95718 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PLD2 | O14939 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809349 | 0.90 | ESR1 (0.49) | ESR1ESR2KMT2A | |
| SCHEMBL2477011 | 0.78 | ESR1 (0.65) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL8810633 | 0.78 | ESR1 (0.65) | ESR1ESR2KDM4EALDH1A1TP53 | |
| SCHEMBL8678271 | 0.78 | ESR2 (0.56) | ESR2KDM4EMEN1TP53MAPT | |
| SCHEMBL8809268 | 0.77 | ESR1 (0.65) | ESR1ESR2KDM4EALDH1A1TP53 | |
| SCHEMBL28294662 | 0.76 | RIPK2 (0.54) | ESR1ESR2 | |
| SCHEMBL7538119 | 0.74 | ESR1 (0.55) | ESR1ESR2BRAF | |
| SCHEMBL8209160 | 0.73 | ESR1 (0.54) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL2474466 | 0.71 | ESR1 (0.48) | ESR1ESR2ESRRGESRRBKDM4E | |
| SCHEMBL8827961 | 0.71 | ESR1 (0.46) | ESR1ESR2ESRRGESRRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997004778-A1 | PYRIDINE COMPOUNDS, INTERMEDIATES, PROCESSES, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1997-02-13 | — | — | WO | disclosed |