Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 12/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484103 | 0.86 | AGTR1 (0.47) | AGTR1LTB4R2PTGDR2ABCB11GP6 | |
| SCHEMBL8486521 | 0.84 | AGTR1 (0.40) | AGTR1LTB4R2PTGDR2PKMABCB11 | |
| SCHEMBL3087 | 0.84 | AGTR1 (0.55) | AGTR1LTB4R2ABCB11GP6AGTR2 | |
| SCHEMBL8810049 | 0.83 | AGTR1 (0.39) | AGTR1LTB4R2PTGDR2PKMABCB11 | |
| SCHEMBL8807538 | 0.81 | AGTR1 (0.52) | AGTR1LTB4R2PTGDR2ABCB11GP6 | |
| SCHEMBL8910748 | 0.80 | AGTR1 (0.36) | AGTR1LTB4R2PTGDR2PKMAGTR2 | |
| SCHEMBL8805767 | 0.79 | AGTR1 (0.34) | AGTR1LTB4R2PTGDR2PKM | |
| SCHEMBL8487512 | 0.77 | AGTR1 (0.46) | AGTR1LTB4R2PTGDR2PKMABCB11 | |
| SCHEMBL8486075 | 0.76 | AGTR1 (0.36) | AGTR1LTB4R2PTGDR2PKMAGTR2 | |
| SCHEMBL2230 | 0.75 | AGTR1 (0.51) | AGTR1LTB4R2ABCB11GP6AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | claimed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |