Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812495 | 0.93 | TNF (0.39) | HTR6NPC1RAB9ANOD2ALDH1A1 | |
| SCHEMBL8809642 | 0.91 | HTR6 (0.36) | HTR6NPC1RAB9ANOD2ALDH1A1 | |
| SCHEMBL8810446 | 0.90 | PPARG (0.38) | HTR6NPC1RAB9ANOD2ALDH1A1 | |
| SCHEMBL8808816 | 0.90 | HTR6 (0.34) | HTR6NPC1RAB9ANOD2ALDH1A1 | |
| SCHEMBL8811311 | 0.88 | NPC1 (0.50) | NPC1RAB9ANOD2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8813825 | 0.87 | CYP19A1 (0.39) | HTR6ALDH1A1CYP19A1MAPTKDM4E | |
| SCHEMBL8685833 | 0.87 | HTR6 (0.43) | HTR6ALDH1A1CYP19A1KMT2A | |
| SCHEMBL8811090 | 0.86 | KDM1A (0.38) | ALDH1A1 | |
| SCHEMBL8810754 | 0.86 | PARP1 (0.41) | HTR6ALDH1A1SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL8810937 | 0.85 | TNF (0.40) | HTR6TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | claimed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |