Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832426 | 0.83 | ALOX5 (0.71) | ALOX5POLBPKM | |
| SCHEMBL8807773 | 0.79 | ALOX5 (0.66) | ALOX5POLBPKMTHRB | |
| SCHEMBL9539738 | 0.77 | ALOX5 (0.61) | ALOX5POLBPKM | |
| SCHEMBL8807572 | 0.76 | ALOX5 (0.64) | ALOX5POLB | |
| SCHEMBL9542469 | 0.76 | ALOX5 (0.60) | ALOX5POLBPKM | |
| SCHEMBL9539758 | 0.75 | ALOX5 (0.58) | ALOX5 | |
| SCHEMBL8806200 | 0.73 | ALOX5 (1.00) | ALOX5POLBPKM | |
| SCHEMBL9539727 | 0.73 | ALOX5 (0.56) | ALOX5PKM | |
| Hydrochloric Acid SCHEMBL27614741 | 0.72 | ALOX5 (0.56) | ALOX5POLBPKMTHRB | |
| SCHEMBL17801568 | 0.72 | ALOX5 (0.56) | ALOX5POLBPKMTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320628-B1 | Substituted furan compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5112848-A | Antiasthmatics and antiarthritic agents | ABBOTT LABORATORIES (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0388429-A4 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0388429-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-09-26 | — | — | EP | disclosed |
| EP-0320628-A1 | Substituted furan compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase | ABBOTT LABORATORIES (US) | 1989-06-21 | — | — | EP | disclosed |
| WO-1989004299-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-05-18 | — | — | WO | disclosed |