SCHEMBL8809883

SCHEMBL8809883

COC(=O)c1cc(C(=O)c2ccccc2)ccc1OC

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.63
CYP2C19 P33261 2/20 0.63
HPGD P15428 2/20 0.63
CYP2D6 P10635 1/20 0.63
MAPT P10636 5/20 0.57
ALDH1A1 P00352 5/20 0.57
RAB9A P51151 1/20 0.57
PTGS1 P23219 1/20 0.57
PTGS2 P35354 1/20 0.57
CYP3A4 P08684 2/20 0.54
TSHR P16473 2/20 0.54
CYP2C9 P11712 1/20 0.54
KDM4E B2RXH2 3/20 0.54
HSD17B10 Q99714 3/20 0.54
MAPK1 P28482 2/20 0.54
ALOX15 P16050 1/20 0.53
ATM Q13315 2/20 0.52
HTT P42858 3/20 0.51
NPSR1 Q6W5P4 2/20 0.51
GAA P10253 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6931187 0.92 CYP1A2 (0.63) CYP1A2CYP2C19HPGDCYP2D6MAPT
SCHEMBL8751765 0.89 HPGD (0.69) CYP1A2CYP2C19HPGDCYP2D6MAPT
SCHEMBL8082162 0.87 HPGD (0.71) CYP1A2CYP2C19HPGDCYP2D6MAPT
SCHEMBL8806128 0.87 MAPT (0.55) CYP1A2CYP2C19HPGDMAPTALDH1A1
SCHEMBL2890368 0.86 ALDH1A1 (0.57) CYP1A2CYP2C19HPGDCYP2D6MAPT
SCHEMBL8807005 0.85 NPC1 (0.56) CYP1A2CYP2C19HPGDCYP2D6MAPT
SCHEMBL27586077 0.85 TSHR (0.55) CYP1A2CYP2C19HPGDCYP2D6MAPT
SCHEMBL30456978 0.83 CA12 (0.65) HPGDMAPTALDH1A1RAB9ATSHR
SCHEMBL5168276 0.83 CA12 (0.65) HPGDMAPTALDH1A1RAB9ATSHR
SCHEMBL29678875 0.83 MAPT (0.64) CYP1A2CYP2C19HPGDMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5663179-A CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS LABORATOIRES GLAXO SA (FR) 1997-09-02 US disclosed
EP-0649410-B1 ANILIDE DERIVATIVES GLAXO LAB SA (FR) 1997-05-02 EP disclosed
EP-0649410-A1 ANILIDE DERIVATIVES. GLAXO LAB SA (FR) 1995-04-26 EP disclosed
WO-1994001408-A1 ANILIDE DERIVATIVES LABORATOIRES GLAXO S.A. (FR) 1994-01-20 WO disclosed