SCHEMBL8810360

SCHEMBL8810360

COc1ccc(C(=O)N2CCNCC2)cc1OC

nearest known ligand 0.64

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.64
POLB P06746 1/20 0.64
CYP2C19 P33261 1/20 0.64
HPGD P15428 2/20 0.60
MAPK1 P28482 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
GAA P10253 2/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
MAPT P10636 1/20 0.60
ATM Q13315 1/20 0.60
PKM P14618 1/20 0.60
LMNA P02545 3/20 0.59
HSD17B10 Q99714 1/20 0.58
TP53 P04637 1/20 0.57
HTT P42858 1/20 0.57
KDM4E B2RXH2 1/20 0.56
KMT2A Q03164 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9621229 0.98 ALDH1A1 (0.63) ALDH1A1POLBCYP2C19HPGDMAPK1
SCHEMBL11300155 0.88 PKM (0.57) ALDH1A1POLBCYP2C19HPGDL3MBTL1
SCHEMBL29531267 0.88 PKM (0.57) ALDH1A1POLBCYP2C19HPGDL3MBTL1
SCHEMBL18753965 0.88 PKM (0.57) ALDH1A1POLBCYP2C19HPGDMAPK1
SCHEMBL15566861 0.87 LRRK2 (0.54) ALDH1A1POLBCYP2C19HPGDL3MBTL1
SCHEMBL8608730 0.85 HPGD (0.57) ALDH1A1POLBCYP2C19HPGDL3MBTL1
SCHEMBL29944081 0.84 HPGD (0.76) ALDH1A1POLBCYP2C19HPGDMAPK1
SCHEMBL12474523 0.84 TP53 (0.49) ALDH1A1POLBCYP2C19HPGDMAPK1
SCHEMBL11091860 0.84 NPC1 (0.63) ALDH1A1HPGDL3MBTL1SMN1; SMN2HSD17B10
SCHEMBL16542023 0.84 TP53 (0.49) ALDH1A1POLBCYP2C19HPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0257102-B1 AGENTS FOR TREATING NEUROPHATHY MITSUI PETROCHEMICAL IND (JP) 1997-11-19 EP disclosed
EP-0799617-A2 Therapeutic agent for neurological diseases MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1997-10-08 EP disclosed
EP-0168003-B1 OXINDOL COMPOUNDS, COMPOSITIONS CONTAINING SAME AND PROCESSES FOR PREPARING SAME OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1991-04-03 EP disclosed
US-4959368-A PYRIMIDINE DERIVATIVES MITSUI PETROCHEMICAL INDUSTRIES LTD. (JP) 1990-09-25 US disclosed
EP-0242957-B1 1-SUBSTITUTED ALKYL-1, 2-DIHYDRO-2-PYRAZINONE DERIVATIVES TOYO JOZO KABUSHIKI KAISHA (JP) 1990-09-12 EP disclosed
US-4877875-A ANTIAGGLOMERANTS, VASODILATORS TOYO JOZO KABUSHIKI KAISHA (JP) 1989-10-31 US disclosed
US-4837319-A VASODILATORS, ANTICOAGULANTS TOYO JOZO KABUSHIKI KAISHA (JP) 1989-06-06 US disclosed
US-4737501-A Substituted piperazinyl oxindol compounds and cardiotonic compositions containing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1988-04-12 US disclosed
EP-0257102-A1 AGENTS FOR TREATING NEUROPHATHY Mitsui Chemicals, Inc. (JP) 1988-03-02 EP disclosed
EP-0242957-A1 1-Substituted Alkyl-1, 2-Dihydro-2-Pyrazinone derivatives TOYO JOZO KABUSHIKI KAISHA (JP) 1987-10-28 EP disclosed
US-4585774-A Aniline derivatives and cardiotonic composition OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1986-04-29 US disclosed
EP-0064878-B1 NOVEL ANILINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND CARDIOTONIC COMPOSITIONS CONTAINING THE SAME OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1985-07-24 EP disclosed
US-4415572-A CARDIOTONIC AND INOTROPIC AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1983-11-15 US disclosed
EP-0064878-A1 Novel aniline derivatives, process for preparing the same and cardiotonic compositions containing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1982-11-17 EP disclosed