Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 16/20 | 0.43 |
| ▸ | BCL9 | O00512 | 14/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809258 | 0.90 | ROCK2 (0.57) | ROCK2GAANPSR1CTNNB1BCL9 | |
| SCHEMBL8809779 | 0.87 | GAA (0.52) | GAANPSR1 | |
| SCHEMBL9056936 | 0.85 | GAA (0.50) | GAANPSR1 | |
| SCHEMBL8814244 | 0.85 | GAA (0.44) | ROCK2GAANPSR1 | |
| SCHEMBL8807180 | 0.84 | GAA (0.49) | GAANPSR1 | |
| SCHEMBL8817749 | 0.84 | NPSR1 (0.49) | GAANPSR1 | |
| SCHEMBL8808422 | 0.84 | TP53 (0.52) | GAANPSR1 | |
| SCHEMBL9057638 | 0.84 | GAA (0.43) | ROCK2GAANPSR1 | |
| SCHEMBL8809768 | 0.83 | GAA (0.48) | GAANPSR1 | |
| SCHEMBL8807213 | 0.83 | USP2 (0.45) | ROCK2GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |