Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 3/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813934 | 0.90 | PARP1 (0.48) | PARP1APPSNCA | |
| SCHEMBL8685967 | 0.90 | PARP1 (0.50) | PARP1APPSNCAHTR6SIRT1 | |
| SCHEMBL8811687 | 0.89 | PARP1 (0.58) | PARP1APPSNCAHTR6 | |
| SCHEMBL8808802 | 0.89 | CSNK2A2 (0.51) | PARP1PIM1PIM2HDAC3HDAC4 | |
| SCHEMBL8812081 | 0.88 | PARP1 (0.46) | PARP1PIM1APP | |
| SCHEMBL8811086 | 0.87 | PARP1 (0.76) | PARP1IGF1RPIM1PIM2 | |
| SCHEMBL8690614 | 0.87 | PARP1 (0.76) | PARP1IGF1RPIM1PIM2 | |
| SCHEMBL8810595 | 0.87 | NPM1 (0.50) | PARP1APPSNCA | |
| SCHEMBL8810203 | 0.87 | PARP1 (0.50) | PARP1PIM1PIM2APP | |
| SCHEMBL8812775 | 0.86 | KMT2A (0.48) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |