Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811799 | 0.89 | PARP1 (0.56) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8811126 | 0.89 | PARP1 (0.74) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8811130 | 0.89 | PARP1 (0.74) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8813331 | 0.88 | PARP1 (0.47) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8810780 | 0.85 | PARP1 (0.66) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8809356 | 0.85 | PARP1 (0.79) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8814205 | 0.80 | MAPT (0.70) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8812826 | 0.79 | PARP1 (0.57) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8810454 | 0.78 | PARP1 (0.43) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8811790 | 0.78 | PARP1 (0.73) | PARP1SMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |