Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.47 |
| ▸ | PIM1 | P11309 | 4/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | ADCYAP1R1 | P41586 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813321 | 0.89 | PARP1 (0.60) | PARP1PIM1PIM2TTRCISD1 | |
| SCHEMBL8810478 | 0.89 | PARP1 (0.60) | PARP1PIM1PIM2TTRCISD1 | |
| SCHEMBL8810454 | 0.89 | PARP1 (0.43) | PARP1PIM1PIM2TTRMEN1 | |
| SCHEMBL8811136 | 0.88 | PARP1 (0.58) | PARP1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8811389 | 0.86 | PARP1 (0.62) | PARP1PIM1PIM2TTRCISD1 | |
| SCHEMBL8810203 | 0.86 | PARP1 (0.50) | PARP1PIM1PIM2GCGRADCYAP1R1 | |
| SCHEMBL8812036 | 0.85 | PARP1 (0.54) | PARP1PIM1PIM2TTRCISD1 | |
| SCHEMBL8812716 | 0.81 | PARP1 (0.43) | PARP1PIM1PIM2MEN1ALDH1A1 | |
| SCHEMBL8685272 | 0.80 | GCGR (0.42) | PARP1GCGRADCYAP1R1MEN1ALDH1A1 | |
| SCHEMBL8813512 | 0.80 | ALDH1A1 (0.53) | PARP1MEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |