Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20221777 | 0.83 | HPGD (0.70) | HPGDNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL20346420 | 0.82 | HPGD (0.64) | HPGDNPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL11333992 | 0.81 | NPC1 (0.55) | HPGDNPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL720937 | 0.81 | HPGD (0.68) | HPGDNPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL6263973 | 0.81 | HPGD (0.68) | HPGDNPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL408382 | 0.81 | HPGD (1.00) | HPGDNPC1RAB9AALDH1A1MAPT | |
| SCHEMBL31165739 | 0.81 | CYP1A2 (0.69) | HPGDNPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL26110834 | 0.80 | NPC1 (0.59) | HPGDNPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL21887193 | 0.80 | NPC1 (0.79) | HPGDNPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL12897993 | 0.79 | HPGD (0.70) | HPGDNPC1RAB9ACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267176-A | Amino or acylamino-substituted pyrimidinyl cephalosporanic acid derivatives and pharmaceutical compositions thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-05-12 | — | — | US | claimed |
| WO-2021151865-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2021-08-05 | — | — | WO | disclosed |
| CN-1188394-A | Arthropodicidal and fungicidal cyclic amides | DU PONT (US) | 1998-07-22 | — | — | CN | disclosed |
| WO-1997000612-A1 | ARTHROPODICIDAL AND FUNGICIDAL CYCLIC AMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1997-01-09 | — | — | WO | disclosed |
| US-5166165-A | Sulfonyl-1,3,4-oxadiazole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | disclosed |
| EP-0486798-A1 | Fungicidal agents based on heterocyclic substituted sulphones | BAYER AG (DE) | 1992-05-27 | — | — | EP | disclosed |