Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811234 | 0.81 | HPGD (0.68) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL6263971 | 0.81 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2TP53PTGS2 | |
| SCHEMBL6245001 | 0.81 | HPGD (0.67) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL21887193 | 0.80 | NPC1 (0.79) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL6266686 | 0.77 | NPC1 (0.68) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL31165739 | 0.77 | CYP1A2 (0.69) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL28357227 | 0.76 | IMPDH2 (0.55) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL21041343 | 0.75 | KDM4E (0.47) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2310156 | 0.75 | NPC1 (0.60) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2677612 | 0.74 | NPC1 (0.64) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267176-A | Amino or acylamino-substituted pyrimidinyl cephalosporanic acid derivatives and pharmaceutical compositions thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-05-12 | — | — | US | claimed |