Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811573 | 1.00 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL9595515 | 0.78 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL11597389 | 0.75 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2PKMCYP1A2 | |
| SCHEMBL9005346 | 0.73 | RAB9A (0.55) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL12402230 | 0.72 | AKR1C1 (0.51) | NPC1RAB9ASMN1; SMN2TP53CYP1A2 | |
| SCHEMBL9603810 | 0.71 | GAA (0.43) | NPC1RAB9ASMN1; SMN2PKMCYP1A2 | |
| SCHEMBL10440049 | 0.68 | TDP1 (0.39) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL1976586 | 0.68 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL1976587 | 0.68 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2PKMTP53 | |
| SCHEMBL13715632 | 0.67 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2PKMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462834-B1 | Process for producing pyrido[1,2-a]pyrimidine derivatives | WAKO PURE CHEM IND LTD (JP) | 1997-08-13 | — | — | EP | disclosed |
| EP-0462834-A1 | Process for producing pyrido [1,2-a]pyrimidine derivative | WAKO PURE CHEMICAL INDUSTRIES, LTD (JP) | 1991-12-27 | — | — | EP | disclosed |