Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973969 | 0.79 | TSHR (0.69) | MAPK1TSHRCA1CA2MMP1 | |
| SCHEMBL27989339 | 0.78 | ERN1 (0.53) | ERN1MAPK1MAPTPOLBTDP1 | |
| SCHEMBL28153444 | 0.76 | AHR (0.52) | ERN1MAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL9251355 | 0.75 | TSHR (0.58) | MAPK1TSHRCA1CA2MMP1 | |
| SCHEMBL19475454 | 0.75 | ERN1 (0.50) | ERN1MAPK1MAPTPOLBTDP1 | |
| SCHEMBL27807542 | 0.74 | MAPK1 (0.49) | MAPK1TSHRCA1CA2MMP1 | |
| SCHEMBL3090591 | 0.73 | TAAR1 (0.52) | ERN1MAPK1MAPTPOLBTDP1 | |
| SCHEMBL1478380 | 0.72 | MAPT (0.66) | MAPK1TSHRMAPTRAB9AKDM4E | |
| SCHEMBL11729892 | 0.71 | MAPT (0.67) | MAPK1MAPTPOLBRAB9ANPC1 | |
| SCHEMBL1314970 | 0.71 | NR4A2 (0.54) | ERN1MAPTPOLBRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997013767-A1 | HETEROCYCLICALLY-SUBSTITUTED 1-INDOLE CARBOXAMIDES AS CYCLO-OXYGENASE-2 INHIBITORS | CHEMISCH PHARMAZEUTISCHE FORSCHUNGSGESELLSCHAFT MBH (AT) | 1997-04-17 | — | — | WO | disclosed |