Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813041 | 0.77 | ALDH1A1 (0.40) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL8811223 | 0.76 | TDP1 (0.45) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL8813933 | 0.74 | TP53 (0.39) | MAPTLMNAHTTCYP3A4CYP1A2 | |
| SCHEMBL27172738 | 0.72 | ALDH1A1 (0.42) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL27172737 | 0.72 | ALDH1A1 (0.42) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL24440370 | 0.71 | TDP1 (0.47) | MAPTALDH1A1SMN1; SMN2TDP1CYP3A4 | |
| SCHEMBL16951965 | 0.71 | ALDH1A1 (0.44) | MAPTALDH1A1SMN1; SMN2HTTTDP1 | |
| SCHEMBL24440071 | 0.70 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2LMNATDP1CYP3A4 | |
| SCHEMBL16957720 | 0.70 | TDP1 (0.46) | MAPTALDH1A1SMN1; SMN2TDP1CYP3A4 | |
| SCHEMBL358770 | 0.70 | TDP1 (0.61) | MAPTALDH1A1SMN1; SMN2TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |