Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810637 | 0.91 | PPARG (0.43) | PPARGFFAR1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL8809588 | 0.90 | PARP1 (0.47) | PPARGFFAR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8810752 | 0.89 | PPARG (0.45) | PPARGFFAR1HTR6MAPTALDH1A1 | |
| SCHEMBL8812572 | 0.88 | PPARG (0.50) | PPARGFFAR1MAPTALDH1A1PPARA | |
| SCHEMBL8811277 | 0.88 | FFAR1 (0.45) | PPARGFFAR1MAPTALDH1A1CYP2C9 | |
| SCHEMBL8685830 | 0.87 | PPARG (0.47) | PPARGFFAR1HTR6MAPTALDH1A1 | |
| SCHEMBL8811153 | 0.87 | PPARG (0.53) | PPARGFFAR1HTR6MAPTALDH1A1 | |
| SCHEMBL8814118 | 0.87 | PPARG (0.45) | PPARGFFAR1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8810658 | 0.87 | PPARG (0.42) | PPARGFFAR1MAPTALDH1A1PPARA | |
| SCHEMBL8811924 | 0.87 | MAPT (0.55) | PPARGFFAR1HTR6MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | claimed |
| CN-1167111-A | Thiazolidinedione derivatives, method for preparing derivatives and pharmaceutical compositions containing same | SENGA PHARMACEUTICAL LAB INC (JP) | 1997-12-10 | — | — | CN | disclosed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |