Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 7/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | DBH | P09172 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811190 | 0.93 | PARP1 (0.47) | TDP1ALDH1A1LMNASMN1; SMN2PARP1 | |
| SCHEMBL8811687 | 0.90 | PARP1 (0.58) | ALDH1A1LMNASMN1; SMN2PARP1HTR6 | |
| SCHEMBL8811994 | 0.89 | PARP1 (0.46) | TDP1ALDH1A1LMNASMN1; SMN2PARP1 | |
| SCHEMBL8685967 | 0.88 | PARP1 (0.50) | ALDH1A1LMNASMN1; SMN2PARP1HTR6 | |
| SCHEMBL8809171 | 0.88 | PARP1 (0.48) | ALDH1A1LMNAPARP1SLC2A1HTR6 | |
| SCHEMBL8812789 | 0.88 | SMN1; SMN2 (0.62) | TDP1ALDH1A1LMNASMN1; SMN2PARP1 | |
| SCHEMBL8813667 | 0.88 | PARP1 (0.61) | TDP1ALDH1A1LMNASMN1; SMN2PARP1 | |
| SCHEMBL8690587 | 0.88 | PARP1 (0.61) | TDP1ALDH1A1LMNASMN1; SMN2PARP1 | |
| SCHEMBL8811389 | 0.87 | PARP1 (0.62) | ALDH1A1LMNASMN1; SMN2PARP1PIM1 | |
| SCHEMBL8812716 | 0.86 | PARP1 (0.43) | TDP1ALDH1A1LMNASMN1; SMN2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |