Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 2/20 | 0.68 |
| ▸ | TK2 | O00142 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8813666 | 1.00 | TK1 (0.68) | TK1TK2LMNASMN1; SMN2 | |
| SCHEMBL9780562 | 0.92 | TK1 (0.81) | TK1TK2LMNASMN1; SMN2 | |
| SCHEMBL9780573 | 0.92 | TK1 (0.81) | TK1TK2LMNASMN1; SMN2 | |
| SCHEMBL12983958 | 0.91 | TK1 (0.63) | TK1TK2LMNASMN1; SMN2 | |
| Edoxudine SCHEMBL5983091 | 0.89 | TK1 (0.84) | TK1TK2LMNASMN1; SMN2 | |
| Edoxudine SCHEMBL5983087 | 0.89 | TK1 (0.84) | TK1TK2LMNASMN1; SMN2 | |
| Edoxudine SCHEMBL65579 | 0.89 | TK1 (0.84) | TK1TK2LMNASMN1; SMN2 | |
| Edoxudine SCHEMBL21389875 | 0.89 | TK1 (0.84) | TK1TK2LMNASMN1; SMN2 | |
| Edoxudine SCHEMBL12370767 | 0.89 | TK1 (0.84) | TK1TK2LMNASMN1; SMN2 | |
| Edoxudine SCHEMBL65580 | 0.89 | TK1 (0.84) | TK1TK2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997006178-A1 | PYRIMIDINE NUCLEOSIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-02-20 | — | — | WO | disclosed |
| US-5010060-A | Method of treating herpes simplex viral infection employing pyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-04-23 | — | — | US | disclosed |
| US-4956346-A | URIDINE DERIVATIVES AS VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1990-09-11 | — | — | US | disclosed |
| US-4886785-A | VIRICIDES, HERPES SIMPLEX | HOFFMANN-LA ROCHE INC. (US) | 1989-12-12 | — | — | US | disclosed |
| US-4851519-A | AMIDO NUCLEOSIDES, VIRICIDES | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |
| US-4841039-A | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents | EMORY UNIVERSITY (US) | 1989-06-20 | — | — | US | disclosed |
| US-4681933-A | 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1987-07-21 | — | — | US | disclosed |