SCHEMBL8813974

SCHEMBL8813974

c1ccc(Oc2cn3ccccc3n2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.49
PTGS2 P35354 1/20 0.49
KDM4E B2RXH2 9/20 0.47
NPC1 O15118 11/20 0.46
RAB9A P51151 11/20 0.46
PKM P14618 3/20 0.46
EPHX2 P34913 1/20 0.46
SMN1; SMN2 Q16637 6/20 0.43
ALDH1A1 P00352 3/20 0.43
MAPK1 P28482 1/20 0.43
POLB P06746 1/20 0.42
NFKB1 P19838 2/20 0.41
NFKB2 Q00653 2/20 0.41
RELA Q04206 2/20 0.41
ALOX12 P18054 1/20 0.41
GFER P55789 1/20 0.41
TLR9 Q9NR96 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10431770 0.87 KDM4E (0.64) KDM4ENPC1RAB9APKMEPHX2
SCHEMBL10431674 0.87 RAB9A (0.55) PTGS1PTGS2KDM4ENPC1RAB9A
SCHEMBL9980858 0.87 KDM4E (0.59) PTGS1PTGS2KDM4ENPC1RAB9A
SCHEMBL10431771 0.84 KDM4E (0.53) PTGS1PTGS2KDM4ENPC1RAB9A
SCHEMBL3317159 0.78 NPC1 (0.57) PTGS1PTGS2KDM4ENPC1RAB9A
SCHEMBL12797442 0.77 RAB9A (0.73) PTGS1PTGS2KDM4ENPC1RAB9A
SCHEMBL15064465 0.77 LPL (0.42) KDM4ENPC1RAB9APKMEPHX2
SCHEMBL14889067 0.77 KDM4E (0.38) PTGS1PTGS2KDM4ENPC1RAB9A
SCHEMBL9760182 0.76 PTGS1 (0.58) PTGS1PTGS2KDM4ENPC1RAB9A
SCHEMBL12473753 0.75 NPC1 (0.53) PTGS1PTGS2KDM4ENPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997011075-A1 TRIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-03-27 WO disclosed