Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 4/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811307 | 0.83 | BCHE (0.45) | KDM4EALDH1A1MEN1KMT2ABCHE | |
| SCHEMBL8807896 | 0.83 | MAPT (0.53) | KDM4EALDH1A1MEN1KMT2ABCHE | |
| SCHEMBL8808069 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1MEN1KMT2ABCHE | |
| SCHEMBL8808848 | 0.79 | SMN1; SMN2 (0.46) | ALDH1A1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL8812389 | 0.76 | BCHE (0.50) | BCHECYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8812666 | 0.76 | NOS1 (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL27099852 | 0.75 | KDM4E (0.68) | KDM4EALDH1A1MEN1KMT2ABCHE | |
| SCHEMBL8883322 | 0.74 | KDM4E (0.70) | KDM4EALDH1A1MEN1KMT2ABCHE | |
| Trifluoroacetic Acid SCHEMBL9057618 | 0.74 | HDAC3 (0.41) | — | |
| SCHEMBL27293615 | 0.73 | LTA4H (0.59) | KDM4ELMNATSHRCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |