Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808731 | 0.88 | MAPT (0.48) | MAOBADORA2BMAPTMCHR1HDAC1 | |
| SCHEMBL8831013 | 0.87 | MAPT (0.48) | MAOBADORA2BMAPTMCHR1HDAC1 | |
| SCHEMBL8808353 | 0.86 | MAPT (0.47) | MAOBADORA2BMAPTMCHR1HDAC1 | |
| SCHEMBL8810137 | 0.83 | MAPT (0.40) | MAOBADORA2BMAPTNPC1RAB9A | |
| SCHEMBL8815533 | 0.81 | KDR (0.48) | MAOBADORA2BMAPTMCHR1HDAC1 | |
| SCHEMBL8808377 | 0.81 | MAPT (0.40) | MAOBADORA2BMAPTNPC1RAB9A | |
| SCHEMBL8815521 | 0.80 | ACHE (0.52) | MAPTKDRKDM4EALDH1A1LMNA | |
| SCHEMBL8808718 | 0.79 | MAPT (0.48) | MAOBADORA2BMAPTMCHR1HDAC1 | |
| SCHEMBL8808344 | 0.79 | ACHE (0.49) | MAOBADORA2BMAPTTP53KDR | |
| SCHEMBL8807078 | 0.79 | MAPT (0.46) | MAPTNPC1RAB9ATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |