Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.37 |
| ▸ | GAPDH | P04406 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | STAT6 | P42226 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10101548 | 0.91 | POLRMT (0.40) | POLRMTHIF1ADOT1LGAPDHADORA3 | |
| SCHEMBL19101808 | 0.89 | HIF1A (0.46) | POLRMTHIF1ADOT1LGAPDHADORA3 | |
| SCHEMBL10154369 | 0.89 | HIF1A (0.46) | POLRMTHIF1ADOT1LGAPDHADORA3 | |
| SCHEMBL24982322 | 0.89 | HIF1A (0.46) | POLRMTHIF1ADOT1LGAPDHADORA3 | |
| SCHEMBL25008855 | 0.89 | HIF1A (0.46) | POLRMTHIF1ADOT1LGAPDHADORA3 | |
| SCHEMBL24982409 | 0.89 | HIF1A (0.46) | POLRMTHIF1ADOT1LGAPDHADORA3 | |
| SCHEMBL16710417 | 0.89 | HIF1A (0.46) | POLRMTHIF1ADOT1LGAPDHADORA3 | |
| SCHEMBL806951 | 0.86 | POLRMT (0.40) | POLRMTHIF1ADOT1LGAPDHADORA3 | |
| SCHEMBL16479516 | 0.86 | POLRMT (0.40) | POLRMTHIF1ADOT1LGAPDHADORA3 | |
| SCHEMBL19101901 | 0.86 | POLRMT (0.40) | POLRMTHIF1ADOT1LGAPDHADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906579-B1 | 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION | IDENIX PHARMACEUTICALS LLC (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-2552931-B1 | STEREOSELECTIVE SYNTHESIS OF PHOSPHORUS CONTAINING ACTIVES | GILEAD PHARMASSET LLC (US) | 2014-07-23 | — | — | EP | disclosed |
| WO-2012039787-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012012465-A1 | METHODS FOR THE PREPARATION OF DIASTEROMERICALLY PURE PHOSPHORAMIDATE PRODRUGS | CLARKE, MICHAEL, O'NEIL HANRAHAN (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2011150288-A1 | 1'-SUBSTITUTED-CARBA-NUCLEOSIDE PRODRUGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2011-12-01 | — | — | WO | disclosed |