Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8815866 | 1.00 | ADRA1A (0.38) | ADRA1AHSD11B1DRD2 | |
| Hydrochloric Acid SCHEMBL9867763 | 0.76 | ADRA1A (0.57) | ADRA1AHSD11B1DRD2 | |
| SCHEMBL23043336 | 0.74 | P2RX7 (0.36) | — | |
| SCHEMBL8808442 | 0.74 | ADRA1A (0.34) | ADRA1AHSD11B1DRD2 | |
| SCHEMBL8808448 | 0.74 | ADRA1A (0.34) | ADRA1AHSD11B1DRD2 | |
| SCHEMBL9121303 | 0.73 | DRD1 (0.49) | HSD11B1DRD2 | |
| SCHEMBL9121299 | 0.73 | DRD1 (0.49) | HSD11B1DRD2 | |
| SCHEMBL8168607 | 0.73 | DRD1 (0.49) | HSD11B1DRD2 | |
| SCHEMBL23980356 | 0.73 | P2RX7 (0.33) | — | |
| SCHEMBL1874596 | 0.72 | ADRA1A (0.49) | ADRA1AHSD11B1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586525-B1 | CARBOXAMIDO-(1,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES | UPJOHN CO (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5486611-A | CENTRAL NERVOUS SYSTEM | THE UPJOHN COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0586525-A1 | CARBOXAMIDO-(1,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES. | UPJOHN CO (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992020655-A1 | CARBOXAMIDO-(1,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-11-26 | — | — | WO | disclosed |