Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10034797 | 0.93 | KDM4E (0.38) | KDM4EMAPTLMNAKMT2ACSNK2A1 | |
| SCHEMBL881347 | 0.86 | KDM4E (0.44) | KDM4EMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL10067201 | 0.86 | ALOX5 (0.37) | KDM4EMAPTLMNAKMT2ACSNK2A1 | |
| SCHEMBL10034793 | 0.82 | KDM4E (0.43) | KDM4EMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL10034796 | 0.82 | POLB (0.35) | KDM4EMAPTLMNAKMT2ACSNK2A1 | |
| SCHEMBL881625 | 0.74 | KDM4E (0.61) | KDM4EMAPTLMNAKMT2ACSNK2A1 | |
| SCHEMBL881622 | 0.69 | KDM4E (0.41) | KDM4EMAPTNPSR1HTTALDH1A1 | |
| SCHEMBL881325 | 0.62 | KDM4E (0.78) | KDM4EMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL10034802 | 0.62 | KDM4E (0.54) | KDM4EMAPTLMNAKMT2ANPSR1 | |
| SCHEMBL21450877 | 0.61 | POLB (0.54) | KDM4EMAPTLMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040389-A2 | SUBSTITUTED BICYCLIC HCV INHIBITORS | PRESIDIO PHARMACEUTICALS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2010111673-A1 | SUBSTITUTED BICYCLIC HCV INHIBITORS | PRESIDIO PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |