Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8814922 | 0.88 | BRD4 (0.39) | PARP1PARP2AMY1AMAPTTP53 | |
| SCHEMBL8818631 | 0.86 | ACHE (0.42) | PARP1PARP2AMY1AMAPTTP53 | |
| SCHEMBL8814888 | 0.86 | ACHE (0.44) | PARP1PARP2AMY1AMAPTTP53 | |
| SCHEMBL8079418 | 0.85 | PARP1 (0.41) | PARP1PARP2AMY1AMAPTTP53 | |
| SCHEMBL8818782 | 0.85 | KDM4E (0.35) | PARP1MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8818853 | 0.81 | PARP1 (0.58) | PARP1PARP2AMY1AMAPTTP53 | |
| SCHEMBL8814849 | 0.80 | PARP1 (0.49) | PARP1PARP2AMY1AMAPTTP53 | |
| SCHEMBL8817564 | 0.79 | ACHE (0.44) | PARP1ADORA2ADHODH | |
| SCHEMBL8816611 | 0.74 | ACHE (0.44) | PARP1MAPTTP53KDM4EALDH1A1 | |
| SCHEMBL8818593 | 0.74 | ACHE (0.46) | PARP1MAPTTP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | claimed |
| WO-1997033873-A1 | METHODS OF TREATING OR PREVENTING INTERSTITIAL CYSTITIS | ELI LILLY AND COMPANY (US) | 1997-09-18 | — | — | WO | disclosed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |