Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 4/20 | 0.65 |
| ▸ | MMP2 | P08253 | 4/20 | 0.60 |
| ▸ | MMP13 | P45452 | 4/20 | 0.60 |
| ▸ | MMP9 | P14780 | 3/20 | 0.60 |
| ▸ | MMP8 | P22894 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2249949 | 0.85 | HPSE (0.67) | HPSEMMP2MMP13MMP9MMP8 | |
| SCHEMBL2244714 | 0.80 | HPSE (0.79) | HPSEMMP2MMP13MMP9MMP8 | |
| SCHEMBL943034 | 0.80 | HPSE (1.00) | HPSEMMP2MMP13MMP9MMP8 | |
| SCHEMBL6533676 | 0.80 | HPSE (1.00) | HPSEMMP2MMP13MMP9MMP8 | |
| SCHEMBL2244957 | 0.79 | SMN1; SMN2 (0.77) | HPSEMMP2MMP13MMP9MMP8 | |
| SCHEMBL10954635 | 0.78 | HPSE (0.71) | HPSEMMP2MMP13MMP9MMP8 | |
| SCHEMBL8818654 | 0.78 | HPSE (0.67) | HPSEMMP2MMP13MMP9MMP8 | |
| SCHEMBL7851030 | 0.77 | HPSE (0.79) | HPSEMMP2MMP13MMP9MMP8 | |
| SCHEMBL8820296 | 0.77 | MMP2 (0.82) | HPSEMMP2MMP13MMP9MMP8 | |
| SCHEMBL6532513 | 0.77 | HPSE (0.87) | HPSEMMP2MMP13MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997036866-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF HEPATITIS C | VIROPHARMA INCORPORATED (US) | 1997-10-09 | — | — | WO | disclosed |