Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 8/20 | 1.00 |
| ▸ | MMP2 | P08253 | 3/20 | 0.75 |
| ▸ | MMP9 | P14780 | 3/20 | 0.75 |
| ▸ | MMP8 | P22894 | 3/20 | 0.75 |
| ▸ | MMP13 | P45452 | 3/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533676 | 1.00 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6532513 | 0.93 | HPSE (0.87) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6506352 | 0.93 | HPSE (0.87) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6503052 | 0.93 | HPSE (0.87) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6506260 | 0.91 | MMP2 (0.93) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6529592 | 0.89 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6530058 | 0.89 | NPC1 (0.83) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6528065 | 0.89 | HPSE (0.79) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL2244714 | 0.88 | HPSE (0.79) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL7851030 | 0.88 | HPSE (0.79) | HPSEMMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250204515-A1 | Heparanase Inhibition for Graft Protection | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2025-06-26 | — | — | US | claimed |
| WO-2023175581-A1 | HEPARANASE INHIBITION FOR GRAFT PROTECTION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2023-09-21 | — | — | WO | claimed |
| EP-2543396-B1 | ARTIFICIAL SKIN | SHISEIDO CO LTD (JP) | 2019-04-10 | — | — | EP | claimed |
| EP-3381906-A1 | COMPOUNDS FOR USE AS HEPARANASE INHIBITORS | Leadiant Biosciences SA (CH) | 2018-10-03 | — | — | EP | claimed |
| US-8871505-B2 | Artificial skin | SHISEIDO COMPANY, LTD. (JP) | 2014-10-28 | — | — | US | claimed |
| US-20250204515-A1 | Heparanase Inhibition for Graft Protection | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2025-06-26 | — | — | US | disclosed |
| US-20250041189-A1 | STEM CELL PROLIFERATION PROMOTER | SHISEIDO COMPANY, LTD. (JP) | 2025-02-06 | — | — | US | disclosed |
| EP-4442811-A1 | STEM CELL PROLIFERATION PROMOTER | Shiseido Company, Ltd. (JP) | 2024-10-09 | — | — | EP | disclosed |
| EP-3878970-B1 | LAMININ 511 PRODUCTION PROMOTER, BASAL EPIDERMAL LAYER STABILIZER AND/OR SCREENING METHOD FOR AGENT TO MINIMIZE REDUCTION IN OR PROMOTE INCREASE IN EPIDERMAL STEM CELLS | SHISEIDO CO LTD (JP) | 2024-09-11 | — | — | EP | disclosed |
| CN-118202039-A | Stem cell proliferation promoter | 株式会社资生堂 | 2024-06-14 | — | — | CN | disclosed |
| US-20230404885-A1 | EPIDERMAL STEM CELL PROLIFERATION-PROMOTING AGENT | SHISEIDO COMPANY, LTD. (JP) | 2023-12-21 | — | — | US | disclosed |
| WO-2023175581-A1 | HEPARANASE INHIBITION FOR GRAFT PROTECTION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2023-09-21 | — | — | WO | disclosed |
| EP-2543396-A1 | ARTIFICIAL SKIN | Shiseido Company, Ltd. (JP) | 2013-01-09 | — | — | EP | disclosed |
| US-20130006355-A1 | ARTIFICIAL SKIN | SHISEIDO COMPANY, LTD. | 2013-01-03 | — | — | US | disclosed |
| US-20120328719-A1 | EXTERNAL PREPARATION FOR SKIN | SHISEIDO COMPANY, LTD. | 2012-12-27 | — | — | US | disclosed |
| EP-2484359-A1 | HEPARANASE ACTIVITY INHIBITOR | SHISEIDO CO., LTD. (JP) | 2012-08-08 | — | — | EP | disclosed |
| US-20120183481-A1 | HEPARANASE ACTIVITY INHIBITOR | SHISEIDO COMPANY, LTD. (JP) | 2012-07-19 | — | — | US | disclosed |
| EP-2295028-A1 | PREPARATION FOR PREVENTING OR AMELIORATING WRINKLES, TO BE TAKEN ORALLY, THROUGH INJECTION, OR THROUGH EXTERNAL APPLICATION TO SKIN, AND COSMETIC METHOD | Shiseido Company, Ltd. (JP) | 2011-03-16 | — | — | EP | disclosed |
| US-20110020477-A1 | ORAL PREPARATION, INJECTION PREPARATION, EXTERNAL SKIN PREPARATION AND COSMETIC METHOD FOR PREVENTING OR IMPROVING WRINKLES | SHISEIDO COMPANY, LTD. | 2011-01-27 | — | — | US | disclosed |
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250204515-A1 | Heparanase Inhibition for Graft Protection | HPSE, ENGASE, HPN | HPSE 1/4885MMP2 62/4885MMP9 190/4885 |
| US-20230404885-A1 | EPIDERMAL STEM CELL PROLIFERATION-PROMOTING AGENT | MKI67, KRT18, KIT | HPSE 609/4885MMP2 2511/4885MMP9 3240/4885 |
| US-20250041189-A1 | STEM CELL PROLIFERATION PROMOTER | PCNA, IGFBP2, TCF12 | HPSE 237/4885MMP2 2180/4885MMP9 648/4885 |
| US-20120183481-A1 | HEPARANASE ACTIVITY INHIBITOR | HPSE, HEXA, ENGASE | HPSE 1/4885MMP2 24/4885MMP9 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.