Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RB1 | P06400 | 7/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29824229 | 0.82 | PARP1 (0.49) | RB1KDM4EALDH1A1 | |
| SCHEMBL23537222 | 0.82 | PARP1 (0.49) | RB1KDM4EALDH1A1 | |
| SCHEMBL8822941 | 0.81 | SMN1; SMN2 (0.46) | RB1SIGMAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8582769 | 0.80 | SIGMAR1 (0.47) | RB1SIGMAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29824454 | 0.78 | PARP1 (0.51) | RB1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL23537449 | 0.78 | PARP1 (0.51) | RB1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30023161 | 0.78 | PARP1 (0.51) | RB1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14473893 | 0.76 | BRD3 (0.58) | RB1SIGMAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28912217 | 0.76 | NR2E1 (0.50) | RB1SIGMAR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28183138 | 0.76 | NR2E1 (0.46) | RB1SIGMAR1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997000069-A1 | MELATONIN AGONISTS FOR TREATING BENIGN PROSTATIC HYPERPLASIA | ELI LILLY AND COMPANY (US) | 1997-01-03 | — | — | WO | claimed |
| EP-0748627-A2 | Melatonin agonists for use in the treatment of benign prostatic hyperplasia | ELI LILLY AND COMPANY (US) | 1996-12-18 | — | — | EP | claimed |
| WO-1997000069-A1 | MELATONIN AGONISTS FOR TREATING BENIGN PROSTATIC HYPERPLASIA | ELI LILLY AND COMPANY (US) | 1997-01-03 | — | — | WO | disclosed |