Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD1 | P21728 | 2/20 | 0.51 |
| ▸ | HTR1B | P28222 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8823806 | 0.92 | HTR1A (0.57) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL2217080 | 0.82 | HTR1A (0.66) | HTR1ADRD2DRD1HTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL9620015 | 0.81 | HTR1A (0.65) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL5759457 | 0.80 | DRD2 (0.51) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL4838334 | 0.80 | DRD2 (0.51) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL4830434 | 0.80 | DRD2 (0.51) | HTR1ADRD2DRD1HTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL6823030 | 0.79 | DRD2 (0.50) | HTR1ADRD2DRD1HTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL8155838 | 0.79 | DRD2 (0.50) | HTR1ADRD2DRD1HTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL4834479 | 0.79 | DRD2 (0.50) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL6387318 | 0.78 | HTR1A (0.53) | HTR1ADRD2DRD1HTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656657-A | Chroman derivatives | ASTRA AKTIEBOLAG (SE) | 1997-08-12 | — | — | US | disclosed |
| US-5656658-A | Method for the treatment of anxiety | ASTRA AKTIEBOLAG (SE) | 1997-08-12 | — | — | US | disclosed |
| US-5650524-A | Process for preparing (R)-3-amino-5-methoxychroman | ASTRA AKTIEBOLAG (SE) | 1997-07-22 | — | — | US | disclosed |
| US-5646309-A | Intermediates in the synthesis of chroman derivatives | ASTRA AKTIEBOLAG (SE) | 1997-07-08 | — | — | US | disclosed |
| US-5641807-A | Method for the treatment of depression | ASTRA AKTIEBOLAG (SE) | 1997-06-24 | — | — | US | disclosed |
| US-5639772-A | Chroman derivatives | ASTRA AKTIEBOLAG (SE) | 1997-06-17 | — | — | US | disclosed |
| US-5639784-A | ADMINISTERING 3-AMINO-5-CARBAMOYL-CHROMENES AND DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1997-06-17 | — | — | US | disclosed |
| US-5500425-A | Chroman derivatives and a method of treating 5-HT mediated disorders | AKTIEBOLAGET ASTRA (SE) | 1996-03-19 | — | — | US | disclosed |
| US-5420151-A | Chroman derivatives | AKTIEBOLAGET ASTRA (SE) | 1995-05-30 | — | — | US | disclosed |