Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8824306 | 0.95 | HRH3 (0.46) | HRH3NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL8824308 | 0.90 | HRH3 (0.43) | HRH3NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL6587925 | 0.84 | HRH3 (0.54) | HRH3NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL8824294 | 0.83 | HRH3 (0.41) | HRH3KDM4EMAPTBACE1HTT | |
| SCHEMBL8824283 | 0.80 | KDM4E (0.46) | HRH3KDM4EALDH1A1CYP2D6MAPT | |
| SCHEMBL3942245 | 0.80 | KDM4E (0.53) | HRH3KDM4EALDH1A1CYP2D6MAPT | |
| SCHEMBL4447566 | 0.78 | KDM4E (0.51) | HRH3KDM4EALDH1A1CYP2D6MAPT | |
| SCHEMBL11608427 | 0.75 | ACHE (0.65) | NPC1RAB9AKMT2AMAOBALDH1A1 | |
| SCHEMBL4149468 | 0.75 | ACHE (0.65) | NPC1RAB9AKMT2AMAOBALDH1A1 | |
| SCHEMBL471858 | 0.73 | KDM4E (0.60) | HRH3KDM4EALDH1A1HPGDCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612474-A | ANTIBODIES AND IMMUNOLOGY | ELI LILLY AND COMPANY (US) | 1997-03-18 | — | — | US | disclosed |