Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PPIA | P62937 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | LIPE | Q05469 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897966 | 0.82 | NPC1 (0.68) | LTA4HMAPK14ABCB1HTR1ANPC1 | |
| SCHEMBL8526782 | 0.79 | LTA4H (0.66) | LTA4HMAPK14MAPTMAPK1TDP1 | |
| SCHEMBL30711987 | 0.78 | LTA4H (0.64) | LTA4HMAPK14MAPTMAPK1TDP1 | |
| SCHEMBL1805748 | 0.78 | LTA4H (0.64) | LTA4HMAPK14MAPTMAPK1TDP1 | |
| SCHEMBL2645138 | 0.78 | LTA4H (0.64) | LTA4HMAPK14MAPTMAPK1TDP1 | |
| SCHEMBL105010 | 0.78 | LTA4H (1.00) | LTA4HMAPK14MAPTMAPK1TDP1 | |
| SCHEMBL31121576 | 0.78 | LTA4H (0.64) | LTA4HMAPK14MAPTMAPK1TDP1 | |
| SCHEMBL1563544 | 0.78 | LTA4H (0.64) | LTA4HMAPK14MAPTMAPK1TDP1 | |
| SCHEMBL2339072 | 0.78 | LTA4H (0.64) | LTA4HMAPK14MAPTMAPK1TDP1 | |
| SCHEMBL27759692 | 0.78 | LTA4H (0.64) | LTA4HMAPK14MAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |
| EP-0651745-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002464-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B4 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-03 | — | — | WO | disclosed |