Sugi Predict

Sugi Predict / Compounds / SCHEMBL897966

SCHEMBL897966

SCHEMBL897966

COc1ccc(COc2cccnc2I)cc1

nearest known ligand 0.68

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 2/20 0.68
▸ RAB9A P51151 2/20 0.68
▸ APP P05067 7/20 0.54
▸ ABCB1 P08183 2/20 0.51
▸ HTR1A P08908 1/20 0.46
▸ ADRA1D P25100 1/20 0.46
▸ ADRA1A P35348 1/20 0.46
▸ ADRA1B P35368 1/20 0.46
▸ SYK P43405 2/20 0.46
▸ AURKB Q96GD4 1/20 0.46
▸ INCENP Q9NQS7 1/20 0.46
▸ MAOB P27338 1/20 0.45
▸ CSF1R P07333 1/20 0.45
▸ HTT P42858 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ LTA4H P09960 1/20 0.44
▸ MAPK14 Q16539 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12301192 0.83 NPC1 (0.70) NPC1RAB9AAPPABCB1HTR1A
SCHEMBL8825232 0.82 LTA4H (0.64) NPC1RAB9AAPPABCB1HTR1A
SCHEMBL7237455 0.81 NPC1 (0.68) NPC1RAB9AAPPABCB1HTR1A
SCHEMBL9125665 0.81 NPC1 (1.00) NPC1RAB9AAPPABCB1HTR1A
SCHEMBL16018989 0.79 ABCB1 (0.68) NPC1RAB9AAPPABCB1HTR1A
SCHEMBL1101265 0.79 MEN1 (0.71) NPC1RAB9ASMN1; SMN2
SCHEMBL4518756 0.79 APP (0.60) NPC1RAB9AAPPABCB1HTR1A
SCHEMBL17882844 0.78 NPC1 (0.56) NPC1RAB9AAPPMAOBHTT
SCHEMBL29620944 0.78 NPC1 (0.63) NPC1RAB9AAPPABCB1HTR1A
SCHEMBL7238803 0.78 NPC1 (0.68) NPC1RAB9AABCB1HTR1AADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250332155-A1 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS AURIGENE ONCOLOGY LTD (IN) 2025-10-30 — — US disclosed
US-12377088-B2 Substituted tetrahydroquinolinone compounds as ROR gamma modulators AURIGENE ONCOLOGY LIMITED (IN) 2025-08-05 — — US disclosed
US-20230142119-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-05-11 — — US disclosed
US-20230142119-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-05-11 — — US disclosed
US-20230142119-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-05-11 — — US disclosed
US-20220306578-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-09-29 — — US disclosed
US-20220306578-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-09-29 — — US disclosed
US-20220125780-A1 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS AURIGENE ONCOLOGY LIMITED (IN) 2022-04-28 — — US disclosed
US-20220125780-A1 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS AURIGENE ONCOLOGY LIMITED (IN) 2022-04-28 — — US disclosed
US-11229636-B2 Substituted tetrahydroquinolinone compounds as ROR gamma modulators AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2022-01-25 — — US disclosed
US-9126931-B2 Tetracyclic compound CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-09-08 — — US disclosed
US-20150150845-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-06-04 — — US disclosed
US-20150150845-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-06-04 — — US disclosed
US-20150150845-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-06-04 — — US disclosed
EP-2441753-A1 TETRACYCLIC COMPOUND Chugai Seiyaku Kabushiki Kaisha (JP) 2012-04-18 — — EP disclosed
EP-2441753-A1 TETRACYCLIC COMPOUND Chugai Seiyaku Kabushiki Kaisha (JP) 2012-04-18 — — EP disclosed
US-20120083488-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA 2012-04-05 — — US disclosed
US-20120083488-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA 2012-04-05 — — US disclosed
US-20120083488-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA 2012-04-05 — — US disclosed
WO-2010143664-A1 TETRACYCLIC COMPOUND 中外製薬株式会社 (JP) 2010-12-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230142119-A1 TETRACYCLIC COMPOUND ALK, TTR, ACVR1 NPC1 1969/4885RAB9A 2620/4885APP 736/4885
US-12377088-B2 Substituted tetrahydroquinolinone compounds as ROR gamma modulators RORC, RORA, RORB NPC1 362/4885RAB9A 736/4885APP 2622/4885
US-20120083488-A1 TETRACYCLIC COMPOUND ALK, TTR, ACVR1 NPC1 1969/4885RAB9A 2620/4885APP 736/4885
US-20250332155-A1 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS RORC, RORA, RORB NPC1 362/4885RAB9A 736/4885APP 2622/4885
US-11229636-B2 Substituted tetrahydroquinolinone compounds as ROR gamma modulators RORC, RORA, RORB NPC1 362/4885RAB9A 736/4885APP 2622/4885
US-20220306578-A1 TETRACYCLIC COMPOUND ALK, TTR, ACVR1 NPC1 1969/4885RAB9A 2620/4885APP 736/4885
US-20150150845-A1 TETRACYCLIC COMPOUND ALK, TTR, ACVR1 NPC1 1969/4885RAB9A 2620/4885APP 736/4885
US-20220125780-A1 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS RORC, RORA, RORB NPC1 362/4885RAB9A 736/4885APP 2622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.