Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.57 |
| ▸ | USP10 | Q14694 | 1/20 | 0.56 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.56 |
| ▸ | USP13 | Q92995 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524564 | 0.91 | EGFR (0.50) | EGFRERBB2USP10PIK3C3USP13 | |
| SCHEMBL8825884 | 0.91 | ALDH1A1 (0.55) | EGFRERBB2HTTLMNAKDM4E | |
| SCHEMBL8825593 | 0.90 | EGFR (0.46) | EGFRERBB2USP10PIK3C3USP13 | |
| SCHEMBL8825977 | 0.90 | MAPK1 (0.55) | EGFRERBB2HTTCNR1CNR2 | |
| SCHEMBL8795709 | 0.90 | EGFR (0.49) | EGFRERBB2HTTKDM4EALDH1A1 | |
| SCHEMBL8825839 | 0.89 | EGFR (0.62) | EGFRHTTLMNAKDM4E | |
| SCHEMBL7522588 | 0.89 | EGFR (0.47) | EGFRERBB2USP10PIK3C3USP13 | |
| SCHEMBL7521999 | 0.89 | EGFR (0.50) | EGFRERBB2USP10PIK3C3USP13 | |
| SCHEMBL8825848 | 0.88 | EGFR (0.50) | EGFRERBB2HTTLMNAKDM4E | |
| SCHEMBL8825757 | 0.88 | KDM4E (0.51) | EGFRERBB2HTTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661147-A | CYCLIC GUANOSINE MONOPHOSPHATE-SPECIFIC PHOSPHODIESTERASE INHIBITOR; TREATING CARDIOVASCULAR DISORDER | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0668280-A1 | IMIDAZOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-08-23 | — | — | EP | disclosed |